ID   P3IP1_PONAB             Reviewed;         263 AA.
AC   Q5RCS3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Phosphoinositide-3-kinase-interacting protein 1;
DE   AltName: Full=Kringle domain-containing protein HGFL;
DE   Flags: Precursor;
GN   Name=PIK3IP1; Synonyms=HGFL;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of hepatic phosphatidylinositol 3-kinase
CC       (PI3K) activity. {ECO:0000250|UniProtKB:Q7TMJ8}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96FE7};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR858196; CAH90434.1; -; mRNA.
DR   RefSeq; NP_001125218.1; NM_001131746.1.
DR   AlphaFoldDB; Q5RCS3; -.
DR   STRING; 9601.ENSPPYP00000013087; -.
DR   GeneID; 100172110; -.
DR   KEGG; pon:100172110; -.
DR   CTD; 113791; -.
DR   eggNOG; ENOG502QTWD; Eukaryota.
DR   InParanoid; Q5RCS3; -.
DR   OrthoDB; 1027586at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043553; P:negative regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
DR   CDD; cd00108; KR; 1.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR018056; Kringle_CS.
DR   InterPro; IPR038178; Kringle_sf.
DR   Pfam; PF00051; Kringle; 1.
DR   SMART; SM00130; KR; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS00021; KRINGLE_1; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Kringle; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..263
FT                   /note="Phosphoinositide-3-kinase-interacting protein 1"
FT                   /id="PRO_0000280349"
FT   TOPO_DOM        22..168
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..263
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          24..101
FT                   /note="Kringle"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT   REGION          242..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        25..101
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT   DISULFID        46..82
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT   DISULFID        70..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
SQ   SEQUENCE   263 AA;  28091 MW;  DF62EDC107C1258E CRC64;
     MLLAWVQAFL VSNMLLAEAY GSGGCFWDNG HLYREDQTSP APGLRCLNWL DAQSGLASAP
     VSGAGNHSYC RNPDEDPRGP WCYVSGEAGV PEKRPCENLS CPETTSQALP ASTTEIEEAS
     EGPGADEVQV FAPANALPAR SEAAAVQPVI GISQRVRMNS KEKKDLGTLG YVLGITMMVI
     IVAIGAGIIL GYSYKRGKDL KEQHDQKVCE REMQRITLPL SAFTNPTCEI VDEKTVVVHT
     SQTPVDPQEG STPLMGQAGT PGA