ID   P3URF_HUMAN             Reviewed;          95 AA.
AC   A0A087WWA1;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=PIK3R3 upstream open reading frame protein {ECO:0000305};
GN   Name=P3R3URF {ECO:0000312|HGNC:HGNC:53451};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL672043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AI208897; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS85970.1; -.
DR   RefSeq; NP_001315584.1; NM_001328655.1.
DR   AlphaFoldDB; A0A087WWA1; -.
DR   STRING; 9606.ENSP00000480059; -.
DR   BioMuta; ENSG00000250719; -.
DR   MassIVE; A0A087WWA1; -.
DR   PeptideAtlas; A0A087WWA1; -.
DR   DNASU; 110117498; -.
DR   Ensembl; ENST00000506599.2; ENSP00000480059.2; ENSG00000250719.2.
DR   GeneID; 110117498; -.
DR   KEGG; hsa:110117498; -.
DR   MANE-Select; ENST00000506599.2; ENSP00000480059.2; NM_001328655.2; NP_001315584.1.
DR   UCSC; uc057gct.1; human.
DR   CTD; 110117498; -.
DR   DisGeNET; 110117498; -.
DR   GeneCards; P3R3URF; -.
DR   HGNC; HGNC:53451; P3R3URF.
DR   HPA; ENSG00000250719; Tissue enriched (testis).
DR   neXtProt; NX_A0A087WWA1; -.
DR   VEuPathDB; HostDB:ENSG00000250719; -.
DR   eggNOG; KOG4637; Eukaryota.
DR   GeneTree; ENSGT00700000106049; -.
DR   HOGENOM; CLU_2372156_0_0_1; -.
DR   OMA; SVWILSP; -.
DR   OrthoDB; 1406848at2759; -.
DR   PRO; PR:A0A087WWA1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; A0A087WWA1; protein.
DR   Bgee; ENSG00000250719; Expressed in left testis and 41 other tissues.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..95
FT                   /note="PIK3R3 upstream open reading frame protein"
FT                   /id="PRO_0000446328"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   95 AA;  10952 MW;  2F11C23574F0EB30 CRC64;
     MGPSRLVRGP RPQGMRSPYR RPGMGWPRPR FPRMFKCSRR RYQQGLRGRT ASSAAINPAT
     RAMGINNTHT DTTIVWIFPP QVLRHLRQPG IFLIL