ID   P3_BOVIN                Reviewed;         477 AA.
AC   Q0V8N6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=P3 protein;
DE   AltName: Full=Solute carrier family 10 member 3;
GN   Name=SLC10A3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The ubiquitous expression and the conservation of the
CC       sequence in distant animal species suggest that the gene codes for a
CC       protein with housekeeping functions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC       2.A.28) family. {ECO:0000305}.
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DR   EMBL; BT026182; ABG67021.1; -; mRNA.
DR   EMBL; BC123710; AAI23711.1; -; mRNA.
DR   RefSeq; NP_001068633.1; NM_001075165.1.
DR   RefSeq; XP_010819859.1; XM_010821557.1.
DR   RefSeq; XP_010819860.1; XM_010821558.1.
DR   RefSeq; XP_010819861.1; XM_010821559.2.
DR   AlphaFoldDB; Q0V8N6; -.
DR   SMR; Q0V8N6; -.
DR   STRING; 9913.ENSBTAP00000019057; -.
DR   TCDB; 2.A.28.1.5; the bile acid:na(+) symporter (bass) family.
DR   PaxDb; Q0V8N6; -.
DR   PRIDE; Q0V8N6; -.
DR   Ensembl; ENSBTAT00000019057; ENSBTAP00000019057; ENSBTAG00000014333.
DR   GeneID; 504534; -.
DR   KEGG; bta:504534; -.
DR   CTD; 8273; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014333; -.
DR   VGNC; VGNC:34660; SLC10A3.
DR   eggNOG; KOG2718; Eukaryota.
DR   GeneTree; ENSGT00950000182808; -.
DR   HOGENOM; CLU_034788_2_0_1; -.
DR   InParanoid; Q0V8N6; -.
DR   OMA; CCLFLIT; -.
DR   OrthoDB; 1148347at2759; -.
DR   TreeFam; TF315811; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000014333; Expressed in corpus epididymis and 104 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR   GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR004710; Bilac:Na_transpt.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR030210; SLC10A3.
DR   PANTHER; PTHR10361; PTHR10361; 1.
DR   PANTHER; PTHR10361:SF3; PTHR10361:SF3; 1.
DR   Pfam; PF01758; SBF; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..477
FT                   /note="P3 protein"
FT                   /id="PRO_0000283780"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  50656 MW;  A0FAF54B104321D3 CRC64;
     MVFRSGEGHS LQWPGPEGGT GCTGPQSMLR ATLLLVSLLW GARGTPSASL SPALGHPMPL
     TRGRYLSIGD GSVMEFEFPE ESEGIIVITS QYPGQGNGTG PSPMLRVTSL DPEVLAIKNV
     SSIALGSGGS FVVSIRSGLP GIAPLHIQLT DPREAPPRLI EERRDFCIKV SPAEDTPITL
     GTDLVHFSEN PILYLLLPLI FVNKCSFGCK VELEVLKGLL QNPQPMLLGL LGQFLVMPFY
     AFLMAKVFML PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFI STVAATGFLP
     LSSAIYSRLL SIHETLHVPV SKILGTLLFI AIPIAAGVVI KSKLPKFSQL LLHVIKPFSF
     VLLLGGLFLA YRMGVFILAG VRLPIVLVGF TVPLVGLLVG YGLATCLKLP VAQRRTVSIE
     VGVQNSLLAL AMLQLSLRRL QADYASQAPF LVALSGTSEM LALVIGHFIY SSVCAVP