P3_MOUSE
ID P3_MOUSE Reviewed; 473 AA.
AC P21129; Q8QZR2;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=P3 protein;
DE AltName: Full=Solute carrier family 10 member 3;
GN Name=Slc10a3; Synonyms=P3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-473.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=1973144; DOI=10.1016/0888-7543(90)90184-v;
RA Filippi M., Tribioli C., Toniolo D.;
RT "Linkage and sequence conservation of the X-linked genes DXS253E (P3) and
RT DXS254E (GdX) in mouse and man.";
RL Genomics 7:453-457(1990).
CC -!- FUNCTION: The ubiquitous expression and the conservation of the
CC sequence in distant animal species suggest that the gene codes for a
CC protein with housekeeping functions.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK041958; BAC31110.1; -; mRNA.
DR EMBL; BC023050; AAH23050.1; -; mRNA.
DR EMBL; BC027440; AAH27440.1; -; mRNA.
DR EMBL; J04761; AAA40519.1; -; Genomic_DNA.
DR CCDS; CCDS30231.1; -.
DR PIR; I54222; I54222.
DR RefSeq; NP_001243033.1; NM_001256104.1.
DR RefSeq; NP_663381.1; NM_145406.2.
DR AlphaFoldDB; P21129; -.
DR SMR; P21129; -.
DR STRING; 10090.ENSMUSP00000045150; -.
DR PhosphoSitePlus; P21129; -.
DR PaxDb; P21129; -.
DR PRIDE; P21129; -.
DR Antibodypedia; 17715; 67 antibodies from 17 providers.
DR DNASU; 214601; -.
DR Ensembl; ENSMUST00000037967; ENSMUSP00000045150; ENSMUSG00000032806.
DR Ensembl; ENSMUST00000073067; ENSMUSP00000072818; ENSMUSG00000032806.
DR Ensembl; ENSMUST00000114146; ENSMUSP00000109783; ENSMUSG00000032806.
DR GeneID; 214601; -.
DR KEGG; mmu:214601; -.
DR UCSC; uc009tou.2; mouse.
DR CTD; 8273; -.
DR MGI; MGI:95048; Slc10a3.
DR VEuPathDB; HostDB:ENSMUSG00000032806; -.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR InParanoid; P21129; -.
DR OMA; CCLFLIT; -.
DR OrthoDB; 1148347at2759; -.
DR PhylomeDB; P21129; -.
DR TreeFam; TF315811; -.
DR BioGRID-ORCS; 214601; 1 hit in 74 CRISPR screens.
DR PRO; PR:P21129; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; P21129; protein.
DR Bgee; ENSMUSG00000032806; Expressed in decidua and 240 other tissues.
DR ExpressionAtlas; P21129; baseline and differential.
DR Genevisible; P21129; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0010033; P:response to organic substance; IDA:MGI.
DR GO; GO:0032526; P:response to retinoic acid; IDA:MGI.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030210; SLC10A3.
DR PANTHER; PTHR10361; PTHR10361; 1.
DR PANTHER; PTHR10361:SF3; PTHR10361:SF3; 1.
DR Pfam; PF01758; SBF; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..473
FT /note="P3 protein"
FT /id="PRO_0000052344"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 473 AA; 50255 MW; 9A2AD0A005DD1805 CRC64;
MVVKKSRGSS QQLPGLGGQG GCTGFVGMLG TALLFISLPW GAQVMASANI STALGHTSGH
YLSIGDGSVT EFDFPEKSEG IIVISSQYTG QTNGTGPSPI LKVISLDTEV LTIKNVSAIT
WSSGGGFVVG IHSGLAGLAP LHLQLMDFYE APPLLIEERR DFCIRVSPAE DLPSALNTNL
GHFSENPILY LLLPLIFVNK CSFGCKVELE VLKELLQSPQ PMLLGLLGQF LVMPFYAFLM
AKVFMLPKAL ALGLIITCSS PGGGGSYLFS LLLGGDVTLA ISMTFISTVA ATGFLPLSSA
IYSYLLSIHE TLHVPISKIL GTLLFIAIPI AAGVVIKSKL PKFSELLLQV IKPFSFILLL
GGLFLAYHMG VFILVGVRLP IVLVGFTVPL VGLLVGYSLA ICLKLPVAQR RTVSIEVGVQ
NSLLALAMLQ LSLRRLQADY ASQAPFIVAL SGTSEMLALV IGQFIYSILF PVP
