ID   P40_SCHMA               Reviewed;         354 AA.
AC   P12812;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Major egg antigen;
DE   AltName: Full=p40;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Puerto Rican;
RX   PubMed=3097539; DOI=10.1016/0166-6851(86)90021-6;
RA   Nene V., Dunne D.W., Johnson K.S., Taylor D.W., Cordingley J.S.;
RT   "Sequence and expression of a major egg antigen from Schistosoma mansoni.
RT   Homologies to heat shock proteins and alpha-crystallins.";
RL   Mol. Biochem. Parasitol. 21:179-188(1986).
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; M15508; AAA29902.1; -; mRNA.
DR   EMBL; M15509; AAA29903.1; -; mRNA.
DR   EMBL; M15510; AAA29904.1; -; mRNA.
DR   PIR; A54521; A54521.
DR   AlphaFoldDB; P12812; -.
DR   SMR; P12812; -.
DR   STRING; 6183.Smp_049300.3; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   HOGENOM; CLU_046766_0_0_1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   Gene3D; 2.60.40.790; -; 2.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   PANTHER; PTHR45640; PTHR45640; 2.
DR   Pfam; PF00011; HSP20; 2.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 2.
DR   PROSITE; PS01031; SHSP; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..354
FT                   /note="Major egg antigen"
FT                   /id="PRO_0000126062"
FT   DOMAIN          122..233
FT                   /note="sHSP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   DOMAIN          251..354
FT                   /note="sHSP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         98
FT                   /note="M -> I"
SQ   SEQUENCE   354 AA;  39428 MW;  D281FFA84C468FCA CRC64;
     MSGGKQHNAV SIPVNREQRS FEKQRRDLLT GLEHGGGAHR GNSIAPYTED WPSTVDNWID
     SSWKRWDDDM RRLRRGMFAL LPLDTFSIGI LENPFALMHQ MDRQIQDIRE RMGSLDVPST
     GSVNDFLKDA YEVGEDGKVH FKVRFDAQGF APQDINVTSS ENRVTVHAKK ETTTDGRKCS
     REFCRMVQLP KSIDDSQLKC RMTDDGVLML EAPVKVDQNQ SLTLNESGQV AVRPKSDNQI
     KAVPASQALV AKGVHGLSYV DDGSGGKRLH VEVAVDPVYK PEDLFVNVDS NRVVVSGRHH
     KQKSDQHGRS SSFAEFSQSY AIPETVDPLS VSAQVVGNTL VLEAPLEKQH AITH