ID   P46_MESHJ               Reviewed;         416 AA.
AC   P0C0J8; P46192; Q4A9H4; Q600E4;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=46 kDa surface antigen;
DE   AltName: Full=p46;
DE   Flags: Precursor;
GN   Name=p46; OrderedLocusNames=MHJ_0511;
OS   Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110)
OS   (Mycoplasma hyopneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mesomycoplasma.
OX   NCBI_TaxID=262719;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 67-74 AND
RP   338-358.
RX   PubMed=7896725; DOI=10.1128/jb.177.7.1915-1917.1995;
RA   Futo S., Seto Y., Mitsuse S., Mori Y., Suzuki T., Kawai K.;
RT   "Molecular cloning of a 46-kilodalton surface antigen (P46) gene from
RT   Mycoplasma hyopneumoniae: direct evidence of CGG codon usage for
RT   arginine.";
RL   J. Bacteriol. 177:1915-1917(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J / ATCC 25934 / NCTC 10110;
RX   PubMed=16077101; DOI=10.1128/jb.187.16.5568-5577.2005;
RA   Vasconcelos A.T.R., Ferreira H.B., Bizarro C.V., Bonatto S.L.,
RA   Carvalho M.O., Pinto P.M., Almeida D.F., Almeida L.G.P., Almeida R.,
RA   Alves-Junior L., Assuncao E.N., Azevedo V.A.C., Bogo M.R., Brigido M.M.,
RA   Brocchi M., Burity H.A., Camargo A.A., Camargo S.S., Carepo M.S.,
RA   Carraro D.M., de Mattos Cascardo J.C., Castro L.A., Cavalcanti G.,
RA   Chemale G., Collevatti R.G., Cunha C.W., Dallagiovanna B., Dambros B.P.,
RA   Dellagostin O.A., Falcao C., Fantinatti-Garboggini F., Felipe M.S.S.,
RA   Fiorentin L., Franco G.R., Freitas N.S.A., Frias D., Grangeiro T.B.,
RA   Grisard E.C., Guimaraes C.T., Hungria M., Jardim S.N., Krieger M.A.,
RA   Laurino J.P., Lima L.F.A., Lopes M.I., Loreto E.L.S., Madeira H.M.F.,
RA   Manfio G.P., Maranhao A.Q., Martinkovics C.T., Medeiros S.R.B.,
RA   Moreira M.A.M., Neiva M., Ramalho-Neto C.E., Nicolas M.F., Oliveira S.C.,
RA   Paixao R.F.C., Pedrosa F.O., Pena S.D.J., Pereira M., Pereira-Ferrari L.,
RA   Piffer I., Pinto L.S., Potrich D.P., Salim A.C.M., Santos F.R., Schmitt R.,
RA   Schneider M.P.C., Schrank A., Schrank I.S., Schuck A.F., Seuanez H.N.,
RA   Silva D.W., Silva R., Silva S.C., Soares C.M.A., Souza K.R.L., Souza R.C.,
RA   Staats C.C., Steffens M.B.R., Teixeira S.M.R., Urmenyi T.P.,
RA   Vainstein M.H., Zuccherato L.W., Simpson A.J.G., Zaha A.;
RT   "Swine and poultry pathogens: the complete genome sequences of two strains
RT   of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae.";
RL   J. Bacteriol. 187:5568-5577(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ44597.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA04085.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D16682; BAA04085.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017243; AAZ44597.1; ALT_INIT; Genomic_DNA.
DR   PIR; A56153; A56153.
DR   RefSeq; WP_011206345.1; NC_007295.1.
DR   AlphaFoldDB; P0C0J8; -.
DR   SMR; P0C0J8; -.
DR   STRING; 262719.MHJ_0511; -.
DR   PRIDE; P0C0J8; -.
DR   ABCD; P0C0J8; 1 sequenced antibody.
DR   EnsemblBacteria; AAZ44597; AAZ44597; MHJ_0511.
DR   KEGG; mhj:MHJ_0511; -.
DR   eggNOG; COG4213; Bacteria.
DR   HOGENOM; CLU_612270_0_0_14; -.
DR   Proteomes; UP000000548; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Lipoprotein; Membrane; Palmitate;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           28..416
FT                   /note="46 kDa surface antigen"
FT                   /id="PRO_0000041981"
FT   LIPID           28
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           28
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   416 AA;  45401 MW;  F4C5C82DCE704B53 CRC64;
     MLRKKFLYSS AIYATSLASI IAFVAAGCGQ TESGSTSDSK PQAETLKHKV SNDSIRIALT
     DPDNPRWISA QKDIISYVDE TEAATSTITK NQDAQNNWLT QQANLSPAPK GFIIAPENGS
     GVGTAVNTIA DKGIPIVAYD RLITGSDKYD WYVSFDNEKV GELQGLSLAA GLLGKEDGAF
     DSIDQMNEYL KSHMPQETIS FYTIAGSQDD NNSQYFYNGA MKVLKELMKN SQNKIIDLSP
     EGENAVYVPG WNYGTAGQRI QSFLTINKDP AGGNKIKAVG SKPASIFKGF LAPNDGMAEQ
     AITKLKLEGF DTQKIFVTGQ DYNDKAKTFI KDGDQNMTIY KPDKVLGKVA VEVLRVLIAK
     KNKASRSEVE NELKAKLPNI SFKYDNQTYK VQGKNINTIL VSPVIVTKAN VDNPDA