P49_ASFP4
ID P49_ASFP4 Reviewed; 438 AA.
AC P0C9Z7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Minor capsid protein p49 {ECO:0000250|UniProtKB:Q65165};
DE Short=p49;
GN OrderedLocusNames=Pret-087;
OS African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS (ASFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Asfuvirales; Asfarviridae; Asfivirus.
OX NCBI_TaxID=561443;
OH NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kutish G.F., Rock D.L.;
RT "African swine fever virus genomes.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Together with the penton and the other minor capsid proteins
CC (M1249L, p17), forms a complicated network immediately below the outer
CC capsid shell, stabilizing the whole capsid (By similarity). Plays an
CC essential role in the formation of infectious virus particles.
CC Especially required for the formation of the capsid vertices (By
CC similarity). During virion assembly, associates with the membrane and
CC probably mediates the docking of the penton complex to the inner
CC membrane, where it recruits the capsomers to form the penton core (By
CC similarity). {ECO:0000250|UniProtKB:Q65165}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:Q65165}.
CC Note=Localizes in close proximity to the capsid vertices.
CC {ECO:0000250|UniProtKB:Q65165}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the asfivirus p49 structural protein family.
CC {ECO:0000305}.
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DR EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Proteomes; UP000000859; Genome.
PE 3: Inferred from homology;
KW Late protein; Virion.
FT CHAIN 1..438
FT /note="Minor capsid protein p49"
FT /id="PRO_0000373413"
FT REGION 134..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 49330 MW; 914EE44CA6CF4573 CRC64;
MYHDYASKLL ADYRSDPPLW ESDLPRHNRY SDNILNSRYC GNKNGAAPVY NEYTNSPGQA
EKGLQLSDLR NFSFMLNPQH KNIGYGDAQD LEPYSSIPKN KLFNHFKNYR PAFSTHTENL
IKRNVVRTEK KTFPQVSGLK DTQKNCLTQP SSLPSLKNPK NSSVPSTRFS EHTKFFSYED
LPKLRTKGTI KHEQHLGDQM PGQCYNGYIP HQDVYNILCL AHKLPASVEK EIAGRGIPLG
NPHVKPNIEQ ELIKSTSTYT GVPILGPLPP KDSQHGREHQ EFSANRHMLQ VSNILHSVFA
NHSIKPQILE DIPVLNAQLA SIKPVSPFLN KAYQTHYMEN IVTLVPRFKS IANYSSPIPN
YSKRNNGQAE YFDTSKQTIS RHNNYIPKYT GGIGDSKLDS TFPKDFNASS VPLTSAEKDH
SLRGDNSACC ISSISPSL