P4B_FOWPN
ID P4B_FOWPN Reviewed; 657 AA.
AC P17355;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 29-SEP-2021, entry version 67.
DE RecName: Full=Major core protein 4b;
DE AltName: Full=Virion core protein 4b;
DE Short=p4b;
DE Flags: Precursor;
GN OrderedLocusNames=FPV167; ORFNames=FP4B;
OS Fowlpox virus (strain NVSL) (FPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX NCBI_TaxID=928301;
OH NCBI_TaxID=7742; Vertebrata.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FP-9 / Isolate HP-444;
RX PubMed=2541544; DOI=10.1016/0042-6822(89)90380-2;
RA Binns M.M., Boursnell M.E.G., Tomley F.M., Campbell J.;
RT "Analysis of the fowlpoxvirus gene encoding the 4b core polypeptide and
RT demonstration that it possesses efficient promoter sequences.";
RL Virology 170:288-291(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FP-9 / Isolate HP-440;
RX PubMed=9420213; DOI=10.1128/jvi.72.1.170-179.1998;
RA Boulanger D., Green P., Smith T., Czerny C.P., Skinner M.A.;
RT "The 131-amino-acid repeat region of the essential 39-kilodalton core
RT protein of fowlpox virus FP9, equivalent to vaccinia virus A4L protein, is
RT nonessential and highly immunogenic.";
RL J. Virol. 72:170-179(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT "The genome of fowlpox virus.";
RL J. Virol. 74:3815-3831(2000).
CC -!- FUNCTION: Major component of the virion core that undergoes proteolytic
CC processing during the immature virion (IV) to mature virion (MV)
CC transition. Essential for the formation of a structurally normal core
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC virion core wall. {ECO:0000250}.
CC -!- PTM: The precursor is cleaved to a mature protein during virion
CC maturation. Proteolytic cleavage of major core proteins P4a (A10L), P4b
CC (A3L), and VP8 (L4R), which occurs at a late stage of core formation,
CC is required for production of infectious mature virions (MV) (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae protein P4b family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M25781; AAA43817.1; -; Genomic_DNA.
DR EMBL; AJ005164; CAA06406.1; -; Genomic_DNA.
DR EMBL; AF198100; AAF44511.1; -; Genomic_DNA.
DR PIR; A31474; FOVZFV.
DR RefSeq; NP_039130.1; NC_002188.1.
DR GeneID; 1486715; -.
DR KEGG; vg:1486715; -.
DR Proteomes; UP000008597; Genome.
DR InterPro; IPR004972; P4B.
DR Pfam; PF03292; Pox_P4B; 1.
PE 3: Inferred from homology;
KW Reference proteome; Virion.
FT PROPEP 1..61
FT /evidence="ECO:0000250"
FT /id="PRO_0000040587"
FT CHAIN 62..657
FT /note="Major core protein 4b"
FT /id="PRO_0000040588"
SQ SEQUENCE 657 AA; 75217 MW; 78AD757F652C9734 CRC64;
MESDSNIAIE EVKYPNILLE PVYYNNLEVI GSHLHKPDKN NLCNVCDVLN KITEEDVISA
GAKQQRPMRL RSKPKPDICK GVSDSVKQKN TIINIDEITS THDWQYNLRK DADAIVRYLM
DRKCDINNFT IQDLIRVMRE LNIIRNERQE LFELLSHVKG SLSSNSVSVK TSHPLMVIYS
HSDNKIGEQL KLLENTYDPS RYQALIDTTR FQSTNFVDMS TSSDMLFRFK DQDSIGYVHP
ILVALFGVKL PALENAMVLG DSYSLMKQLY NSKKVKPENY MLLINRLTED SPIIFTGIND
SVSSEIHRAS IHTMLRKTIL NLRLGIFYSK DCDLVDNHLM KIIHINSSQM MADEEQMLAS
ILSIVGFRPA LVSITDPYQP LNVVLKPVSY IVVSPSKMIT TINNPISINS NSIYSLSFDN
TTGRVMFMPA NMRYQGTISC RTVDALPVLN SISHDRIINS PVIVNGTLIY YIERRQNKNI
VSGECFTGFR SVINDRPMDI ANELNINGIT YLLKSAVCYK THDLLSTMSG SCDGGDVFLK
GYYTILFTEM GPWMYDPLSI YSKQSRESRL MRVMKNQYYK EHGNDDGMFY DWLKEESTKK
LCDIKQQQLM HHTVMFEDDL LSHEEAMNLI SRNCCILVYA QDYLPYLATK SITEIFV