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P4KA2_ARATH
ID   P4KA2_ARATH             Reviewed;         525 AA.
AC   Q9C680;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Phosphatidylinositol 4-kinase alpha 2;
DE            Short=PI4-kinase alpha 2;
DE            Short=PtdIns-4-kinase alpha 2;
DE            EC=2.7.1.67;
DE   AltName: Full=Phosphatidylinositol 4-OH kinase alpha2;
DE            Short=AtPI4Kalpha2;
DE            Short=PI-4Kalpha2;
GN   Name=PI4KA2; Synonyms=PI4KALPHA2; OrderedLocusNames=At1g51040;
GN   ORFNames=F23H24.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12226484; DOI=10.1104/pp.004770;
RA   Mueller-Roeber B., Pical C.;
RT   "Inositol phospholipid metabolism in Arabidopsis. Characterized and
RT   putative isoforms of inositol phospholipid kinase and phosphoinositide-
RT   specific phospholipase C.";
RL   Plant Physiol. 130:22-46(2002).
CC   -!- FUNCTION: Acts on phosphatidylinositol (PtdIns) in the first committed
CC       step in the production of the second messenger inositol-1,4,5,-
CC       trisphosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC         1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC         H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC         EC=2.7.1.67;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AC079828; AAG50530.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32615.1; -; Genomic_DNA.
DR   PIR; F96547; F96547.
DR   RefSeq; NP_175516.1; NM_103983.2.
DR   AlphaFoldDB; Q9C680; -.
DR   SMR; Q9C680; -.
DR   STRING; 3702.AT1G51040.1; -.
DR   PaxDb; Q9C680; -.
DR   PRIDE; Q9C680; -.
DR   EnsemblPlants; AT1G51040.1; AT1G51040.1; AT1G51040.
DR   GeneID; 841525; -.
DR   Gramene; AT1G51040.1; AT1G51040.1; AT1G51040.
DR   KEGG; ath:AT1G51040; -.
DR   Araport; AT1G51040; -.
DR   TAIR; locus:2026063; AT1G51040.
DR   eggNOG; KOG0902; Eukaryota.
DR   HOGENOM; CLU_011483_1_0_1; -.
DR   InParanoid; Q9C680; -.
DR   OMA; CEEDILM; -.
DR   OrthoDB; 1147978at2759; -.
DR   PhylomeDB; Q9C680; -.
DR   BioCyc; ARA:AT1G51040-MON; -.
DR   PRO; PR:Q9C680; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C680; baseline and differential.
DR   Genevisible; Q9C680; AT.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048; PTHR10048; 2.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   Kinase; Membrane; Reference proteome; Transferase.
FT   CHAIN           1..525
FT                   /note="Phosphatidylinositol 4-kinase alpha 2"
FT                   /id="PRO_0000398593"
FT   DOMAIN          239..509
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          163..278
FT                   /note="Pleckstrin homology (PH) domain conferring
FT                   phosphoinositide binding specificity"
FT                   /evidence="ECO:0000250"
FT   REGION          245..251
FT                   /note="G-loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          373..381
FT                   /note="Catalytic loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          392..417
FT                   /note="Activation loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
SQ   SEQUENCE   525 AA;  59290 MW;  1316625BDF7ECAB8 CRC64;
     MERLNELCDI IEQNPKQFLD KLPWICQQCP QSKLLRAESP RFSQSHLNAI LAVTRILSKI
     VDTTDENAKF VVLDFLQTVP KSFHRSFWPY SLSLESISAF YCSFLGYVSC LSQLMVEGYL
     LRAAQRSDIF AHTLIWHLQG ESVEEIVKDG AFDKNASFQE ILSDVRQHIV DGFTPKALNF
     FSREFDFFEK VTSISGALLP LPKEERVAGI RRELEKIKMQ GEDLYLPTAP NKLVRVIQVD
     SGIPLQSAAK VPIMITFNVV DLDGDHNDVK PQACIFKVGD DCRQDVLALQ VISLLGDIFQ
     AVGLNLYLFP YGVLPTVVPN TRSRSQMGET TDGGLYEIFQ QNYGLVGSTT FETARANFLI
     SSAGYAVASL LLQPKDRHNG NLLFDDVGRL VHIDFGFILE TSPGGNMRFE NAHFKLSHEM
     TQLLDPSGVM KSKTWHQFVS LCVKGYLAAR RYMDEIISTV QMMLESGLPC FSRGDPIGNL
     RKRFHPEMSE REAALFMINV CTDAYNKWTT AGYDLIQYLQ QGVEK
 
 
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