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P4KG8_ARATH
ID   P4KG8_ARATH             Reviewed;         533 AA.
AC   Q0WMZ6; Q9LXY0;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Phosphatidylinositol 4-kinase gamma 8;
DE            Short=AtPI4Kgamma8;
DE            Short=PI-4Kgamma8;
DE            Short=PI4K gamma 8;
DE            EC=2.7.1.67;
GN   Name=PI4KG8; Synonyms=PI4KGAMMA8; OrderedLocusNames=At3g56600;
GN   ORFNames=T5P19_250;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12226484; DOI=10.1104/pp.004770;
RA   Mueller-Roeber B., Pical C.;
RT   "Inositol phospholipid metabolism in Arabidopsis. Characterized and
RT   putative isoforms of inositol phospholipid kinase and phosphoinositide-
RT   specific phospholipase C.";
RL   Plant Physiol. 130:22-46(2002).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=17880284; DOI=10.1042/bj20070959;
RA   Galvao R.M., Kota U., Soderblom E.J., Goshe M.B., Boss W.F.;
RT   "Characterization of a new family of protein kinases from Arabidopsis
RT   containing phosphoinositide 3/4-kinase and ubiquitin-like domains.";
RL   Biochem. J. 409:117-127(2008).
CC   -!- FUNCTION: The phosphorylation of phosphatidylinositol (PI) to PI4P is
CC       the first committed step in the generation of phosphatidylinositol 4,5-
CC       bisphosphate (PIP2), a precursor of the second messenger inositol
CC       1,4,5-trisphosphate (InsP3). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC         1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC         H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC         EC=2.7.1.67;
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE79542.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAF01504.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL163972; CAB88063.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE79542.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002686; AEE79543.2; -; Genomic_DNA.
DR   EMBL; DQ446770; ABE66021.1; -; mRNA.
DR   EMBL; AK229660; BAF01504.1; ALT_INIT; mRNA.
DR   PIR; T49061; T49061.
DR   RefSeq; NP_001319769.1; NM_001339803.1.
DR   RefSeq; NP_001327285.1; NM_001339804.1.
DR   RefSeq; NP_191219.2; NM_115519.3.
DR   AlphaFoldDB; Q0WMZ6; -.
DR   SMR; Q0WMZ6; -.
DR   STRING; 3702.AT3G56600.1; -.
DR   PaxDb; Q0WMZ6; -.
DR   PRIDE; Q0WMZ6; -.
DR   ProteomicsDB; 251361; -.
DR   EnsemblPlants; AT3G56600.2; AT3G56600.2; AT3G56600.
DR   GeneID; 824827; -.
DR   Gramene; AT3G56600.2; AT3G56600.2; AT3G56600.
DR   KEGG; ath:AT3G56600; -.
DR   Araport; AT3G56600; -.
DR   TAIR; locus:2102604; AT3G56600.
DR   eggNOG; KOG2381; Eukaryota.
DR   HOGENOM; CLU_027241_1_1_1; -.
DR   InParanoid; Q0WMZ6; -.
DR   OMA; RIFILCT; -.
DR   OrthoDB; 1273723at2759; -.
DR   PRO; PR:Q0WMZ6; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q0WMZ6; baseline and differential.
DR   Genevisible; Q0WMZ6; AT.
DR   GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR044571; P4KG1-8.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   PANTHER; PTHR45800; PTHR45800; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..533
FT                   /note="Phosphatidylinositol 4-kinase gamma 8"
FT                   /id="PRO_0000423365"
FT   DOMAIN          101..397
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          107..113
FT                   /note="G-loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          243..251
FT                   /note="Catalytic loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          276..302
FT                   /note="Activation loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   BINDING         108..114
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTU6"
FT   BINDING         129
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTU6"
FT   BINDING         210..213
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTU6"
FT   BINDING         278
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTU6"
SQ   SEQUENCE   533 AA;  58376 MW;  87FAAED73C9BF1B8 CRC64;
     MAVALDPLTD RFSQFSRSSQ RCRLQSLTNL DFNFLGFNTK QTNLSASSHS LNNRSVSTPC
     FSISGSNLDG SATPHIEILG GQRVPTVRSL VAEVTIAIVS GAQPLLLPSG LGGAYLLQTE
     KGNNIAVAKP VDEEPLAFNN PKGSGGLTLG QPGMKRSIRV GESGIRELAA YLLDHQGFSS
     VPPTALVRIS HVPFHDRGSD HAAYKVASLQ RFVGHDFDAG ELGPGSFTVV SVHRIGILDV
     RVLNLDRHAG NMLVKKIHDQ DETTCSNGVG AAELVPIDHG LCLPECLDDP YFEWLNWPQA
     SVPFTDIELQ YISNLDPFKD AELLRTELDS IQESSLRVLI VCTIFLKEAA AAGLSLAEIG
     EKMTRDICRG EESSSVLEIL CNKAKASAVS GSDDDDDYSS EWNEVEAELE CGIFQFDDEV
     ECKELPDMLQ VPIFTRVPSI AANLSALMRC PPNQWISTYD TNIEEERRDR SIVRSKSHPI
     CVNYDEKEGV YFGDMSGDEW EMFLHSFQML LPEALEGSTS KGPKPRFGSS CKF
 
 
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