ID   P4R2B_DANRE             Reviewed;         426 AA.
AC   A1L1M4; A8WFX8; Q4V9I7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 2-B;
GN   Name=ppp4r2b; ORFNames=wu:fc23g05;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Egg, Kidney, and Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4
CC       (PP4). {ECO:0000250}.
CC   -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC       different assemblies of the catalytic and one or more regulatory
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PPP4R2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH96878.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI29135.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC096878; AAH96878.1; ALT_INIT; mRNA.
DR   EMBL; BC129134; AAI29135.1; ALT_INIT; mRNA.
DR   EMBL; BC154497; AAI54498.1; -; mRNA.
DR   RefSeq; NP_001103841.1; NM_001110371.1.
DR   AlphaFoldDB; A1L1M4; -.
DR   iPTMnet; A1L1M4; -.
DR   PeptideAtlas; A1L1M4; -.
DR   PRIDE; A1L1M4; -.
DR   Ensembl; ENSDART00000075486; ENSDARP00000069968; ENSDARG00000053447.
DR   GeneID; 100005419; -.
DR   KEGG; dre:100005419; -.
DR   CTD; 100005419; -.
DR   ZFIN; ZDB-GENE-030131-3008; ppp4r2b.
DR   eggNOG; KOG3175; Eukaryota.
DR   GeneTree; ENSGT00940000162859; -.
DR   InParanoid; A1L1M4; -.
DR   OMA; SVPFEDM; -.
DR   OrthoDB; 774806at2759; -.
DR   PhylomeDB; A1L1M4; -.
DR   Reactome; R-DRE-5693607; Processing of DNA double-strand break ends.
DR   PRO; PR:A1L1M4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000053447; Expressed in mature ovarian follicle and 28 other tissues.
DR   ExpressionAtlas; A1L1M4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030289; C:protein phosphatase 4 complex; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   InterPro; IPR015267; PPP4R2.
DR   PANTHER; PTHR16487; PTHR16487; 1.
DR   Pfam; PF09184; PPP4R2; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..426
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 2-B"
FT                   /id="PRO_0000299371"
FT   REGION          161..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         370
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   CONFLICT        21
FT                   /note="A -> P (in Ref. 1; AAI54498)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102
FT                   /note="Q -> R (in Ref. 1; AAH96878)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        145
FT                   /note="S -> R (in Ref. 1; AAH96878)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        204
FT                   /note="P -> L (in Ref. 1; AAI54498)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   426 AA;  46589 MW;  CDB0606C7980E857 CRC64;
     MEIDTLLEAL KDFDKKVKKE ASTVLDQFLC HIAKTGETLV SWSQFKTYFV FKLEKVMEDF
     HASAPEQRGP ANPNVESIPF EEMKERILKI VNEYNGIPFT IQRLCELLTE PKRNYTGTEK
     FLRGVEKNVM VVSCIYPTSE KNGCSGVNRM NGVMLSGNTS AFTERKVNGP GTPRPLNRQK
     HSMSSSLATN GLPDSTENKD TNTPQGHSKT TSDASASGIG GPLGSSVKNK HLDDEEDEGM
     EEEEHEVKRL KFSQDGNEDE EDEDDVDEQV VETPRSTLSK SPSDKSEDPE SPSSMLQEGS
     EEEEEESKHE GSAENSEDQE PSSTQPECPV ADSRETFTER EVPCGSDDSS EEPSDMDQSE
     QRAPAGVASS PELREGEEPS EVSSSSTDDN ASGPTSSSSS IDSPTEGDTG SGALDLESAE
     EPMEQD