ID   P4R3A_XENLA             Reviewed;         820 AA.
AC   Q7ZX60;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3-A {ECO:0000250|UniProtKB:Q5MIZ7};
DE   AltName: Full=SMEK homolog 2-A;
GN   Name=ppp4r3b-a {ECO:0000250|UniProtKB:Q5MIZ7}; Synonyms=smek2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4
CC       (PP4). {ECO:0000250}.
CC   -!- SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in
CC       different assemblies of the catalytic and one or more regulatory
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMEK family. {ECO:0000305}.
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DR   EMBL; BC045225; AAH45225.1; -; mRNA.
DR   RefSeq; NP_001079620.1; NM_001086151.1.
DR   AlphaFoldDB; Q7ZX60; -.
DR   DNASU; 379307; -.
DR   GeneID; 379307; -.
DR   KEGG; xla:379307; -.
DR   CTD; 379307; -.
DR   Xenbase; XB-GENE-6256096; ppp4r3b.L.
DR   OrthoDB; 388216at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 379307; Expressed in blastula and 19 other tissues.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006887; DUF625.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF04802; SMK-1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..820
FT                   /note="Serine/threonine-protein phosphatase 4 regulatory
FT                   subunit 3-A"
FT                   /id="PRO_0000254605"
FT   DOMAIN          1..100
FT                   /note="WH1"
FT   REGION          682..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        696..712
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        750..790
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  93726 MW;  6C8E261F7A19FFB8 CRC64;
     MSDTRRRVKV YTLNEDRQWD DRGTGHVSST YVERLKGMSL LVRAESDGSL LLESKINPNT
     AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVEVT QDPIDESEEE
     RFEEMPETSN LIDLPTCELG KLEEIADLVT SVLSSPIRRE KLALALENEG YIKKLLQLFQ
     TCENLDNTEG LHHLYEIIRG ILFLNKAALF EVMFSDECIM DVVGCLEYDP ALAQPKRHRE
     FLTKTAKFKE VIPITDSELR QKIHQTYRVQ YIQDVILPTP SVFEENFLST LTSFIFFNKV
     EIVSMLQEDE KFLSEVFAQL TDEATDDDKR RELVNFFKEF CAFSQTLQPQ NRDAFFKTLA
     NLGILPALEI VMGMDDLQVR AAATDIFSYL VEFSPSMVRE FVMQEAQQSD DDILLINVVI
     EQMICDSDPE LGGAVQLMGL LRTLIDPENM LATANKTEKS EFLNFFYNHC MHVLTAPLLA
     NTSEDKLEKD AVFGSIKTST VCPDNYQTAQ LLALILELLT FCVEHHTYHI KNYIMNKDLL
     RRVLILMNSK HTFLALCALR FMRRIIGLKD EFYNRYIIKG NLFDPVINAL LDNGTRYNLL
     NSAIIELFEF IRVEDIKSLT SHIVENFYKA LEPIEYVQTF KGLKTRYEQE KDRQSQKLSS
     VPSILRSNRF RRDARALEDD EELWFNEDDE EEGEAVVPPV EKTKPEDDFP EGYEKFLETK
     KAKELEDKEN LPKRTSVGAF KFTFSHSVSA ANGANSTNSK SVAAHTPPAT SNGSSSKNTS
     LTTTVASTKG SLIGLVDYPD DEDEEEEEDA SPRKRPRLGS