P4R3C_HUMAN
ID P4R3C_HUMAN Reviewed; 832 AA.
AC Q6ZMV5; A0A1B0GTN1; Q96M31;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2017, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein PPP4R3C {ECO:0000305};
DE AltName: Full=SMEK homolog 3;
DE AltName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3C {ECO:0000312|HGNC:HGNC:33146};
GN Name=PPP4R3C {ECO:0000312|HGNC:HGNC:33146}; Synonyms=PPP4R3CP, SMEK3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 295-832 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZMV5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZMV5-2; Sequence=VSP_034762;
CC -!- SIMILARITY: Belongs to the SMEK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71482.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK057429; BAB71482.1; ALT_INIT; mRNA.
DR EMBL; AK131475; BAD18620.1; -; mRNA.
DR EMBL; AC006210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS87732.1; -. [Q6ZMV5-1]
DR AlphaFoldDB; Q6ZMV5; -.
DR BioMuta; PPP4R3C; -.
DR DMDM; 206558317; -.
DR EPD; Q6ZMV5; -.
DR MassIVE; Q6ZMV5; -.
DR PeptideAtlas; Q6ZMV5; -.
DR PRIDE; Q6ZMV5; -.
DR ProteomicsDB; 67920; -. [Q6ZMV5-1]
DR ProteomicsDB; 67921; -. [Q6ZMV5-2]
DR Ensembl; ENST00000412172.4; ENSP00000489770.1; ENSG00000224960.5. [Q6ZMV5-1]
DR MANE-Select; ENST00000412172.4; ENSP00000489770.1; NM_207319.4; NP_997202.3.
DR GeneCards; PPP4R3C; -.
DR HGNC; HGNC:33146; PPP4R3C.
DR HPA; ENSG00000224960; Tissue enriched (testis).
DR neXtProt; NX_Q6ZMV5; -.
DR OpenTargets; ENSG00000224960; -.
DR VEuPathDB; HostDB:ENSG00000224960; -.
DR GeneTree; ENSGT00390000018199; -.
DR InParanoid; Q6ZMV5; -.
DR OMA; EFLHFFY; -.
DR PhylomeDB; Q6ZMV5; -.
DR PathwayCommons; Q6ZMV5; -.
DR Pharos; Q6ZMV5; Tdark.
DR PRO; PR:Q6ZMV5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6ZMV5; protein.
DR Bgee; ENSG00000224960; Expressed in right testis and 2 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0030289; C:protein phosphatase 4 complex; IBA:GO_Central.
DR GO; GO:0072542; F:protein phosphatase activator activity; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR006887; DUF625.
DR InterPro; IPR011993; PH-like_dom_sf.
DR Pfam; PF04802; SMK-1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..832
FT /note="Protein PPP4R3C"
FT /id="PRO_0000344447"
FT REGION 708..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..818
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 734..809
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034762"
FT CONFLICT 412..413
FT /note="SD -> IY (in Ref. 1; BAD18620)"
FT /evidence="ECO:0000305"
FT CONFLICT 692
FT /note="V -> A (in Ref. 1; BAD18620/BAB71482)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 832 AA; 95804 MW; F9318B12F14DDB09 CRC64;
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV ILRSQIPPDR
PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA QGKDPSIQTT VNISDEPEED
FNEMSVISNM VVLPDCELNT LDQIADIVTS VFSSPVTDRE RLAEILKNEA YIPKLLQLFH
TCENLENTEG LHHLYEIIKG ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD
FLTNDAKFKE VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ SKDALFETLI
QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE FIISEAHVCK DSDLFINVII
KQMICDTDPE LGGAVHLMVV LHTLLDPRNM LTTPEKSERS EFLHFFYKHC MHKFTAPLLA
ATSEHNCEED DIAGYDKSKN CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR
KALILMNSKH THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER DRQSQIQKNL
HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD DEFMETKRTQ EGEAVMPPLE
DDDKFTETKR THQEGEAVMP PLEDDDEFME TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA
CAAIGTGSPS GSSVVRLVDH PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS
