ID   P4R3C_MOUSE             Reviewed;         813 AA.
AC   Q3V0Y1; A2AG62;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein PPP4R3C {ECO:0000305};
DE   AltName: Full=SMEK homolog 3;
GN   Name=Ppp4r3c; Synonyms=Ppp4r3cp, Smek3p;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SIMILARITY: Belongs to the SMEK family. {ECO:0000305}.
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DR   EMBL; AK132812; BAE21372.1; -; mRNA.
DR   EMBL; AL672285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53129.1; -.
DR   RefSeq; NP_001029052.2; NM_001033880.3.
DR   AlphaFoldDB; Q3V0Y1; -.
DR   STRING; 10090.ENSMUSP00000085471; -.
DR   iPTMnet; Q3V0Y1; -.
DR   PhosphoSitePlus; Q3V0Y1; -.
DR   PaxDb; Q3V0Y1; -.
DR   PRIDE; Q3V0Y1; -.
DR   Ensembl; ENSMUST00000088146; ENSMUSP00000085471; ENSMUSG00000035387.
DR   GeneID; 245511; -.
DR   KEGG; mmu:245511; -.
DR   UCSC; uc012hlr.1; mouse.
DR   MGI; MGI:3588286; 4930415L06Rik.
DR   VEuPathDB; HostDB:ENSMUSG00000035387; -.
DR   eggNOG; KOG2175; Eukaryota.
DR   GeneTree; ENSGT00390000018199; -.
DR   HOGENOM; CLU_004909_3_0_1; -.
DR   InParanoid; Q3V0Y1; -.
DR   OMA; REMINTM; -.
DR   OrthoDB; 388216at2759; -.
DR   PhylomeDB; Q3V0Y1; -.
DR   TreeFam; TF315190; -.
DR   BioGRID-ORCS; 245511; 0 hits in 73 CRISPR screens.
DR   PRO; PR:Q3V0Y1; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q3V0Y1; protein.
DR   Bgee; ENSMUSG00000035387; Expressed in spermatid and 2 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0030289; C:protein phosphatase 4 complex; IBA:GO_Central.
DR   GO; GO:0072542; F:protein phosphatase activator activity; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006887; DUF625.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF04802; SMK-1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..813
FT                   /note="Protein PPP4R3C"
FT                   /id="PRO_0000344448"
FT   REGION          730..813
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        777..801
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        311
FT                   /note="N -> K (in Ref. 1; BAE21372)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   813 AA;  95416 MW;  AB01C10206EC09AC CRC64;
     MTWPSEARPN INMEYRLHTV KVYVMMEDKQ WKNVGTGQIS SKYSEQLQGV CLLVHSLSDG
     SPIMECKIHP NVPYQKQQGK IIIWSEAKNH GMAIHFQEPN DCQEIWEDIC QIQGKDPHVE
     ITQELTDDLE TFEHMPLIWN WVEMSNCEIH TLKNIAELFP FVFEMPSQKE RLALFLENEG
     YIKKLLQLFH TCEKLKNMEG LYYLHNIIKG ILFLNNTRLF NIMFSDEFFM DIVGCLEYDP
     ALDQPKQYRE FLTQNSKFKE VIPIIHSQLR QKIQQTYRMQ YVHDIMLPTP SIFQTNLLSD
     ITTMIFFNKI NIITMIQEDE NFLLEVFSQL KDNSIGDERR IELLLFLKEF CEFAKTLQSQ
     KKNELLKTLI KLGIMSVLKV VVHMNDYQIQ VGALDIFAYL VEYSPCLVRA YAMEEAQDSE
     DNDDLLINIM IKQMICDFDP EFSQGIIMTA VLHELLNPEN MRTTAKGCER KVFLNFFYKR
     YMRKLIAPIL SIRVKYDSND NRVYICPDNY QNAQLLGAVL EILTFCVQYH SMYIKHYIFS
     NNLLRSILVL MSSKHTFLIL CAVRFMRKII GLKDKMYNHY IIKKNLFEPV VNAFMHNGHR
     YNMLNSAIIE LFEFIRKENI TSLIVNIVEN FFRAFKSIEY VQTFKGLKTK YEEEKKRKSQ
     RRKNLHSIMH PKMYYRHIED MEVKVKADIC CRGIIEEEER QGGGEEGAIL PMGSDFTNNY
     DIFMKNKDTN ESESAIEGQK IKSSEASECC PSHGDASATR MSRSHCSSLV PLVDYLYDTD
     DENDDDPYGN DKHEDEHEDE DEEPPPKRPN LST