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P54_ASFK5
ID   P54_ASFK5               Reviewed;         175 AA.
AC   P0C9Z8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Inner membrane protein p54 {ECO:0000305};
DE   AltName: Full=pE183L {ECO:0000250|UniProtKB:Q65194};
GN   OrderedLocusNames=Ken-138;
OS   African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561445;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inner envelope protein involved, through its interaction with
CC       host dynein, in the intracellular microtubule-dependent transport of
CC       viral capsid toward viral factories (By similarity). Seems to induce
CC       caspase-3 activation and apoptosis (By similarity). Plays a role in
CC       virion morphogenesis by recruiting and transforming the host ER
CC       membranes into the precursors of the viral envelope (By similarity).
CC       Involved in virus attachment to the host cell (By similarity).
CC       {ECO:0000250|UniProtKB:Q65194}.
CC   -!- SUBUNIT: Interacts with the host light chain cytoplasmic dynein DYNLL1;
CC       this interaction is critical for intracellular microtubule-dependent
CC       virus transport toward viral factories. {ECO:0000250|UniProtKB:Q65194}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:Q65194};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q65194}. Host
CC       cytoplasm, host cytoskeleton {ECO:0000250|UniProtKB:Q65194}. Host
CC       endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q65194}.
CC       Note=Localizes to the viral factory at 16 hpi. Host DYNLL1 and viral
CC       p54 interact at the microtubular organizing center (By similarity).
CC       Found in the inner envelope of the virus (By similarity).
CC       {ECO:0000250|UniProtKB:Q65194}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the asfivirus envelope protein p54 family.
CC       {ECO:0000305}.
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DR   EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C9Z8; -.
DR   Proteomes; UP000000861; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-KW.
DR   InterPro; IPR008385; ASFV_p54.
DR   Pfam; PF05568; ASFV_J13L; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host cytoplasm; Host cytoskeleton; Host endoplasmic reticulum;
KW   Host membrane; Host-virus interaction; Membrane;
KW   Microtubular outwards viral transport; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Viral release from host cell; Virion.
FT   CHAIN           1..175
FT                   /note="Inner membrane protein p54"
FT                   /id="PRO_0000373416"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          79..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..153
FT                   /note="Interaction with host DYNLL1"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        79..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   175 AA;  18929 MW;  3A2B17D50822C898 CRC64;
     MDSEFFQPVY PRHYGECLSP TSTPSFFSTH MCTILVAIVV LIIIIIVLIY LFSSRKKKAA
     APAIEEEDIQ FINPYQDQQW AGATPQPGTS KPAGATTGNV GKPITDRPAT DRPVTNNPVT
     DRLIMATGGP AAASAPSAEL YTTATTQNTA SQTMPAVEAL RQRSTYTHKD LENSL
 
 
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