ID   P56_BPGA1               Reviewed;         130 AA.
AC   Q9FZX0;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Protein p56 {ECO:0000250|UniProtKB:Q38503};
OS   Bacillus phage GA-1 (Bacteriophage GA-1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Salasmaviridae; Tatarstanvirinae; Gaunavirus.
OX   NCBI_TaxID=2679898;
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Meijer W.J.J., Horcajadas J.A., Salas M.;
RT   "The phi29 family of phages.";
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=21542855; DOI=10.1111/j.1365-2958.2011.07675.x;
RA   Perez-Lago L., Serrano-Heras G., Banos B., Lazaro J.M., Alcorlo M.,
RA   Villar L., Salas M.;
RT   "Characterization of Bacillus subtilis uracil-DNA glycosylase and its
RT   inhibition by phage phi29 protein p56.";
RL   Mol. Microbiol. 80:1657-1666(2011).
CC   -!- FUNCTION: Inhibits the host uracil-DNA glycosylase (UDG), an enzyme
CC       which removes uracil residues from DNA by the base excision repair
CC       (PubMed:21542855). Interacts with host uracil-DNA glycosylase and
CC       prevents the latter from binding to DNA (By similarity). Since the
CC       viral DNA polymerase efficiently incorporates dUMP into DNA, the virus
CC       needs to prevent the deleterious effect caused by host UDG when it
CC       eliminates uracil residues present in the viral genome (By similarity).
CC       {ECO:0000250|UniProtKB:Q38503, ECO:0000269|PubMed:21542855}.
CC   -!- SUBUNIT: Homodimer. Interacts with host UDG; this interaction inhibits
CC       the uracil-DNA glycosylase. {ECO:0000250|UniProtKB:Q38503}.
CC   -!- SIMILARITY: Belongs to the phi29likevirus protein p56 family.
CC       {ECO:0000305}.
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DR   EMBL; X96987; CAC21523.1; -; Genomic_DNA.
DR   RefSeq; NP_073684.1; NC_002649.1.
DR   GeneID; 919881; -.
DR   KEGG; vg:919881; -.
DR   Proteomes; UP000002580; Genome.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction; Reference proteome.
FT   CHAIN           1..130
FT                   /note="Protein p56"
FT                   /id="PRO_0000436074"
SQ   SEQUENCE   130 AA;  15274 MW;  9B5F3711E8DC1918 CRC64;
     MNKEKNSYRD AIKDVELTMM AIDSHFRTHK GFTDSYLLVM ILENEVGETR LEVSEGLTFD
     EVGYIVGSVS DNILHMHTYN YCEKNREDIY KWLKASRIEK FKSDYAKMLM NMHFGKENNV
     GSNINLKEEF