ID   P56_BPPZA               Reviewed;          56 AA.
AC   P06948;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   23-FEB-2022, entry version 55.
DE   RecName: Full=Protein p56 {ECO:0000250|UniProtKB:Q38503};
GN   Name=1B;
OS   Bacillus phage PZA (Bacteriophage PZA).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Salasmaviridae; Picovirinae; Salasvirus; Bacillus virus PZA.
OX   NCBI_TaxID=10757;
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3934048; DOI=10.1016/0378-1119(85)90202-1;
RA   Paces V., Vlcek C., Urbanek P., Hostomsky Z.;
RT   "Nucleotide sequence of the major early region of Bacillus subtilis phage
RT   PZA, a close relative of phi 29.";
RL   Gene 38:45-56(1985).
RN   [2] {ECO:0007744|PDB:4L5N}
RP   X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) OF 2-56.
RX   PubMed=23892286; DOI=10.1093/nar/gkt633;
RA   Cole A.R., Ofer S., Ryzhenkova K., Baltulionis G., Hornyak P., Savva R.;
RT   "Architecturally diverse proteins converge on an analogous mechanism to
RT   inactivate Uracil-DNA glycosylase.";
RL   Nucleic Acids Res. 41:8760-8775(2013).
CC   -!- FUNCTION: Inhibits the host uracil-DNA glycosylase (UDG), an enzyme
CC       which removes uracil residues from DNA by the base excision repair.
CC       Interacts with host uracil-DNA glycosylase and prevents the latter from
CC       binding to DNA. Since the viral DNA polymerase efficiently incorporates
CC       dUMP into DNA, the virus needs to prevent the deleterious effect caused
CC       by host UDG when it eliminates uracil residues present in the viral
CC       genome. {ECO:0000250|UniProtKB:Q38503}.
CC   -!- SUBUNIT: Homodimer. Interacts with host UDG; this interaction inhibits
CC       the uracil-DNA glycosylase (). {ECO:0000250|UniProtKB:Q38503}.
CC   -!- SIMILARITY: Belongs to the phi29likevirus protein p56 family.
CC       {ECO:0000305}.
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DR   EMBL; M11813; AAA88480.1; -; Genomic_DNA.
DR   PIR; B24528; ERBP1B.
DR   PDB; 4L5N; X-ray; 2.16 A; C/D/E/F=2-56.
DR   PDBsum; 4L5N; -.
DR   SMR; P06948; -.
DR   Proteomes; UP000000855; Genome.
PE   1: Evidence at protein level;
KW   3D-structure; Early protein; Host-virus interaction.
FT   CHAIN           1..56
FT                   /note="Protein p56"
FT                   /id="PRO_0000106550"
FT   STRAND          10..17
FT                   /evidence="ECO:0007829|PDB:4L5N"
FT   STRAND          23..31
FT                   /evidence="ECO:0007829|PDB:4L5N"
FT   HELIX           33..42
FT                   /evidence="ECO:0007829|PDB:4L5N"
FT   STRAND          45..54
FT                   /evidence="ECO:0007829|PDB:4L5N"
SQ   SEQUENCE   56 AA;  6580 MW;  2B791F6D5EED39B0 CRC64;
     MVQNDFLDSY DVTMLLQDDN GKQYYEYHKG LSLSDFEVLY GNTVDEIIKL RVDKIS