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P5CR_CAEEL
ID   P5CR_CAEEL              Reviewed;         299 AA.
AC   Q20848;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Putative pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   ORFNames=F55G1.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC         NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline
CC       from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC       {ECO:0000305}.
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DR   EMBL; FO081135; CCD69396.1; -; Genomic_DNA.
DR   PIR; T29226; T29226.
DR   RefSeq; NP_501199.1; NM_068798.5.
DR   AlphaFoldDB; Q20848; -.
DR   SMR; Q20848; -.
DR   BioGRID; 42637; 9.
DR   IntAct; Q20848; 3.
DR   STRING; 6239.F55G1.9; -.
DR   iPTMnet; Q20848; -.
DR   EPD; Q20848; -.
DR   PaxDb; Q20848; -.
DR   PeptideAtlas; Q20848; -.
DR   EnsemblMetazoa; F55G1.9.1; F55G1.9.1; WBGene00018904.
DR   GeneID; 177519; -.
DR   KEGG; cel:CELE_F55G1.9; -.
DR   UCSC; F55G1.9; c. elegans.
DR   CTD; 177519; -.
DR   WormBase; F55G1.9; CE07286; WBGene00018904; -.
DR   eggNOG; KOG3124; Eukaryota.
DR   GeneTree; ENSGT00950000183044; -.
DR   HOGENOM; CLU_042344_3_1_1; -.
DR   InParanoid; Q20848; -.
DR   OMA; PERCFNP; -.
DR   OrthoDB; 952695at2759; -.
DR   PhylomeDB; Q20848; -.
DR   Reactome; R-CEL-8964539; Glutamate and glutamine metabolism.
DR   UniPathway; UPA00098; UER00361.
DR   PRO; PR:Q20848; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00018904; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IBA:GO_Central.
DR   GO; GO:0055129; P:L-proline biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_01925; P5C_reductase; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028939; P5C_Rdtase_cat_N.
DR   InterPro; IPR029036; P5CR_dimer.
DR   InterPro; IPR000304; Pyrroline-COOH_reductase.
DR   PANTHER; PTHR11645; PTHR11645; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   Pfam; PF14748; P5CR_dimer; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..299
FT                   /note="Putative pyrroline-5-carboxylate reductase"
FT                   /id="PRO_0000187321"
SQ   SEQUENCE   299 AA;  32057 MW;  75D2D6D32E0A5670 CRC64;
     MTIDTELTNG SSESVPFVFI GGGNMAAAII KGCQNKGFTP KSNIVIGVQT EKSAEKWRQL
     GYKNVFTNTL EMLERYSTAI YVICVKPQVF EEVVSSWPVN SRPEFIISVM AGVPLKVLNA
     KLPFVSGNTT IVRLMPNVAS SIGAGASTMC YEKNEKIMNQ DSHIELAREF AECVGTVELI
     PERCFNPAMA IGGSSPAWTF MYIESLADGA VAQGLGRAEA KRLAAQAVLG AAQMVLNSNS
     GFDIETQHFG SLKDMVCSPG GTTIEGVRAL EKNGFRYAVM EAVVAASTKA DEMAKSLAK
 
 
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