ID   P5CR_NEUCR              Reviewed;         332 AA.
AC   Q12641; Q7RV72;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=pro-1; ORFNames=NCU06471;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7565596; DOI=10.1007/bf02191601;
RA   Davis C.R., McPeek M.A., McClung C.R.;
RT   "Molecular characterization of the proline-1 (pro-1) locus of Neurospora
RT   crassa, which encodes delta 1-pyrroline-5-carboxylate reductase.";
RL   Mol. Gen. Genet. 248:341-350(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC         NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline
CC       from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA83568.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAA83568.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U30317; AAA83568.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM002238; EAA28126.2; -; Genomic_DNA.
DR   PIR; S57863; S57863.
DR   RefSeq; XP_957362.2; XM_952269.3.
DR   AlphaFoldDB; Q12641; -.
DR   SMR; Q12641; -.
DR   STRING; 5141.EFNCRP00000006245; -.
DR   EnsemblFungi; EAA28126; EAA28126; NCU06471.
DR   GeneID; 3873483; -.
DR   KEGG; ncr:NCU06471; -.
DR   VEuPathDB; FungiDB:NCU06471; -.
DR   HOGENOM; CLU_042344_1_1_1; -.
DR   OMA; VVRVMTN; -.
DR   UniPathway; UPA00098; UER00361.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IBA:GO_Central.
DR   GO; GO:0055129; P:L-proline biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_01925; P5C_reductase; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028939; P5C_Rdtase_cat_N.
DR   InterPro; IPR029036; P5CR_dimer.
DR   InterPro; IPR000304; Pyrroline-COOH_reductase.
DR   PANTHER; PTHR11645; PTHR11645; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   Pfam; PF14748; P5CR_dimer; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..332
FT                   /note="Pyrroline-5-carboxylate reductase"
FT                   /id="PRO_0000187326"
SQ   SEQUENCE   332 AA;  34215 MW;  605F1E2FD6FEEB86 CRC64;
     MAAPQVKSSS ELTMAVLGCG TMGISILSGI LSSLSSIAQD PSPPPTNPPA LPRHFIATVR
     SPSSVAKVES ALSPLVKPSV STLRVLQSTS NVSAAAEADI ILLGCKPYMV SGLLSASGMK
     DALTVKHTEG HARSQKIIIS ICAGVTVPDL ERVLREDVGL SADNLPIVVR AMPNTASKIR
     ESMTVINTVD PPLPDTVTEL LTWIFERIGE VVYLPPHLMD ACTSLCASGT AFFALMMEAA
     ADGGVAMGLP RAEANRMAAQ TMRGAAGLVL EGEHPAILRE KVSTPGGCTI GGLLVLEEGG
     VRAAVARAVR EATVVASLLG GGGAKNVNGT RH