P5CR_SOYBN
ID P5CR_SOYBN Reviewed; 274 AA.
AC P17817;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Pyrroline-5-carboxylate reductase;
DE Short=P5C reductase;
DE Short=P5CR;
DE EC=1.5.1.2;
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2199815; DOI=10.1007/bf00259392;
RA Delauney A.J., Verma D.P.S.;
RT "A soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was
RT isolated by functional complementation in Escherichia coli and is found to
RT be osmoregulated.";
RL Mol. Gen. Genet. 221:299-305(1990).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline
CC from L-glutamate 5-semialdehyde: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed in all plant tissues, but mostly in
CC nodules.
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000305}.
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DR EMBL; X16352; CAA34401.1; -; mRNA.
DR PIR; S10186; S10186.
DR RefSeq; NP_001235914.1; NM_001248985.1.
DR AlphaFoldDB; P17817; -.
DR SMR; P17817; -.
DR STRING; 3847.GLYMA19G31230.1; -.
DR PRIDE; P17817; -.
DR GeneID; 547907; -.
DR KEGG; gmx:547907; -.
DR eggNOG; KOG3124; Eukaryota.
DR HOGENOM; CLU_042344_3_1_1; -.
DR OrthoDB; 952695at2759; -.
DR UniPathway; UPA00098; UER00361.
DR Proteomes; UP000008827; Unplaced.
DR Genevisible; P17817; GM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IBA:GO_Central.
DR GO; GO:0055129; P:L-proline biosynthetic process; IBA:GO_Central.
DR HAMAP; MF_01925; P5C_reductase; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR029036; P5CR_dimer.
DR InterPro; IPR000304; Pyrroline-COOH_reductase.
DR PANTHER; PTHR11645; PTHR11645; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF14748; P5CR_dimer; 1.
DR PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR00112; proC; 1.
DR PROSITE; PS00521; P5CR; 1.
PE 2: Evidence at transcript level;
KW Amino-acid biosynthesis; Cytoplasm; NADP; Oxidoreductase;
KW Proline biosynthesis; Reference proteome.
FT CHAIN 1..274
FT /note="Pyrroline-5-carboxylate reductase"
FT /id="PRO_0000187325"
SQ SEQUENCE 274 AA; 28586 MW; 933CFCFDD7598B63 CRC64;
MEIFPIPAES YTLGFIGAGK MAESIARGAV RSGVLPPSRI RTAVHFNLAR RGAFESFGVT
VLPSNDDVVR ESDVVVLSVK PQLVKDVVSK LTPLLTKHKL LVSVAAGTKL KDLQEWAGND
RFIRVMPNTP AAVGQAASVM SLGGSATEED GNIIAQLFGS IGKIWKAEEK YFDAITGLSG
SGPAYVYLAI EALADGGVAA GLPRDLSLSL ASQTVLGAAS MVSQTGKHPG QLKDDVTSPG
GTTITGIHEL ENGGFRGTLM NAVVAAAKRS RELS
