ID   ASHWN_RAT               Reviewed;         232 AA.
AC   Q5RJT0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Ashwin;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND SER-193, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBUNIT: Component of the tRNA-splicing ligase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BVC5}.
CC   -!- SIMILARITY: Belongs to the ashwin family. {ECO:0000305}.
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DR   EMBL; BC086514; AAH86514.1; -; mRNA.
DR   RefSeq; NP_001008517.1; NM_001008517.1.
DR   AlphaFoldDB; Q5RJT0; -.
DR   SMR; Q5RJT0; -.
DR   STRING; 10116.ENSRNOP00000022601; -.
DR   iPTMnet; Q5RJT0; -.
DR   PhosphoSitePlus; Q5RJT0; -.
DR   PaxDb; Q5RJT0; -.
DR   Ensembl; ENSRNOT00000022601; ENSRNOP00000022601; ENSRNOG00000016447.
DR   GeneID; 301374; -.
DR   KEGG; rno:301374; -.
DR   UCSC; RGD:1310553; rat.
DR   CTD; 301374; -.
DR   RGD; 1310553; RGD1310553.
DR   eggNOG; ENOG502S0PQ; Eukaryota.
DR   GeneTree; ENSGT00390000007488; -.
DR   HOGENOM; CLU_104242_0_0_1; -.
DR   InParanoid; Q5RJT0; -.
DR   OMA; SCNDQHR; -.
DR   OrthoDB; 1299864at2759; -.
DR   PhylomeDB; Q5RJT0; -.
DR   TreeFam; TF332084; -.
DR   PRO; PR:Q5RJT0; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000016447; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; Q5RJT0; RN.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR   GO; GO:0048598; P:embryonic morphogenesis; IEA:InterPro.
DR   InterPro; IPR024887; Ashwin.
DR   PANTHER; PTHR28359; PTHR28359; 1.
DR   Pfam; PF15323; Ashwin; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..232
FT                   /note="Ashwin"
FT                   /id="PRO_0000268861"
FT   REGION          74..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVC5"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVC5"
FT   MOD_RES         184
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVC5"
FT   MOD_RES         189
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         193
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         197
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVC5"
FT   MOD_RES         198
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVC5"
SQ   SEQUENCE   232 AA;  25787 MW;  031D5825145303D7 CRC64;
     MAGDVGGRSC TDAELLLHPE LLSQEFLLLT LEQKNIAVEN DVRVNKDNLT DLYVQHAIPL
     PQRDLPKNRW GKMMEKKREH HEGKNDTKRG SAVDGLRKRP LIVFDGSSTS TSIKVKKTEN
     GADDRLKPPA QTGSTSDSLR KSPNSSSRIA PLVLYSSLPM NNKMEHNNND TKQNHDLTHR
     KSPSGPVKSP PLSPVGTTPV KLKRAAPKEE AEATNHLKPP EAKRKIQHVT WP