ASHWN_XENLA
ID ASHWN_XENLA Reviewed; 226 AA.
AC Q9I8G4; A2VDC9; B3DLS3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Ashwin;
GN Name=c2orf49; Synonyms=asw, asw-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Gastrula;
RX PubMed=16680723; DOI=10.1002/dvdy.20834;
RA Patil S.S., Alexander T.B., Uzman J.A., Lou C.-H., Gohil H., Sater A.K.;
RT "Novel gene ashwin functions in Xenopus cell survival and anteroposterior
RT patterning.";
RL Dev. Dyn. 235:1895-1907(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Intestine, and Neurula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate cell survival and anterior-posterior patterning.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BVC5}.
CC -!- TISSUE SPECIFICITY: Expressed in the neural plate and later in the
CC embryonic brain, eyes, and spinal cord. {ECO:0000269|PubMed:16680723}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Up-
CC regulated in the neural ectoderm after the mid-gastrula stage.
CC {ECO:0000269|PubMed:16680723}.
CC -!- SIMILARITY: Belongs to the ashwin family. {ECO:0000305}.
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DR EMBL; AF281253; AAF82384.2; -; mRNA.
DR EMBL; BC129761; AAI29762.1; -; mRNA.
DR EMBL; BC167560; AAI67560.1; -; mRNA.
DR RefSeq; NP_001080993.1; NM_001087524.1.
DR AlphaFoldDB; Q9I8G4; -.
DR SMR; Q9I8G4; -.
DR BioGRID; 98919; 1.
DR IntAct; Q9I8G4; 1.
DR MaxQB; Q9I8G4; -.
DR GeneID; 394317; -.
DR KEGG; xla:394317; -.
DR CTD; 394317; -.
DR Xenbase; XB-GENE-939826; c2orf49.L.
DR OMA; SRWGKRM; -.
DR OrthoDB; 1299864at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 394317; Expressed in blastula and 19 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEP:AgBase.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IMP:AgBase.
DR GO; GO:0048598; P:embryonic morphogenesis; IMP:AgBase.
DR GO; GO:0042981; P:regulation of apoptotic process; IDA:AgBase.
DR GO; GO:0060062; P:Spemann organizer formation at the dorsal lip of the blastopore; IMP:AgBase.
DR InterPro; IPR024887; Ashwin.
DR PANTHER; PTHR28359; PTHR28359; 1.
DR Pfam; PF15323; Ashwin; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Nucleus; Reference proteome.
FT CHAIN 1..226
FT /note="Ashwin"
FT /id="PRO_0000268864"
FT REGION 89..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 45
FT /note="N -> I (in Ref. 2; AAI29762)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 24783 MW; 8EA60E5D5B1A97C0 CRC64;
MAKAVGSAGI LVKESALLLH PELLSRDFLL LSLERRNIPV EDALNNKEKL TEIFVQHAMP
LPQRDLPRNR WGRMMESKRG ENKIATVLKS AGTEGGRKRP PIVFDGCSTS TTIKVKRTEN
GDASQRLNPS PKESTNSTQN SNPAPRLGSP TPNKEAKVAT TGNHGQLDSL PVTDSALVSP
KSAKLQQSMI INAVKLKRNA PKEEFDVAND TKPTEAKKKI QHVTWP
