P5I11_HUMAN
ID P5I11_HUMAN Reviewed; 189 AA.
AC O14683; Q3ZCS0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tumor protein p53-inducible protein 11;
DE AltName: Full=p53-induced gene 11 protein;
GN Name=TP53I11; Synonyms=PIG11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION BY TP53.
RC TISSUE=Colon cancer;
RX PubMed=9305847; DOI=10.1038/38525;
RA Polyak K., Xia Y., Zweier J.L., Kinzler K.W., Vogelstein B.;
RT "A model for p53-induced apoptosis.";
RL Nature 389:300-306(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: By p53/TP53. {ECO:0000269|PubMed:9305847}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC39533.1; Type=Miscellaneous discrepancy; Note=Localized in an untranslated region: wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AF010315; AAC39533.1; ALT_SEQ; mRNA.
DR EMBL; AK292837; BAF85526.1; -; mRNA.
DR EMBL; AC068858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68052.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68053.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68055.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68057.1; -; Genomic_DNA.
DR EMBL; BC045666; AAH45666.1; -; mRNA.
DR CCDS; CCDS7911.1; -.
DR RefSeq; NP_001245249.1; NM_001258320.1.
DR RefSeq; NP_001245250.1; NM_001258321.1.
DR RefSeq; NP_001245251.1; NM_001258322.1.
DR RefSeq; NP_001245252.1; NM_001258323.2.
DR RefSeq; NP_001245253.1; NM_001258324.1.
DR RefSeq; NP_001305313.1; NM_001318384.1.
DR RefSeq; NP_001305314.1; NM_001318385.1.
DR RefSeq; NP_001305315.1; NM_001318386.1.
DR RefSeq; NP_006025.2; NM_006034.4.
DR RefSeq; XP_005253284.1; XM_005253227.4.
DR RefSeq; XP_011518777.1; XM_011520475.2.
DR RefSeq; XP_011518778.1; XM_011520476.2.
DR RefSeq; XP_011518779.1; XM_011520477.2.
DR RefSeq; XP_011518780.1; XM_011520478.2.
DR RefSeq; XP_016874069.1; XM_017018580.1.
DR RefSeq; XP_016874070.1; XM_017018581.1.
DR AlphaFoldDB; O14683; -.
DR BioGRID; 114913; 36.
DR IntAct; O14683; 10.
DR MINT; O14683; -.
DR STRING; 9606.ENSP00000436152; -.
DR iPTMnet; O14683; -.
DR PhosphoSitePlus; O14683; -.
DR BioMuta; TP53I11; -.
DR EPD; O14683; -.
DR jPOST; O14683; -.
DR MassIVE; O14683; -.
DR MaxQB; O14683; -.
DR PaxDb; O14683; -.
DR PeptideAtlas; O14683; -.
DR PRIDE; O14683; -.
DR ProteomicsDB; 48166; -.
DR Antibodypedia; 26149; 187 antibodies from 27 providers.
DR DNASU; 9537; -.
DR Ensembl; ENST00000308212.9; ENSP00000309532.5; ENSG00000175274.19.
DR Ensembl; ENST00000395648.7; ENSP00000379009.3; ENSG00000175274.19.
DR Ensembl; ENST00000525680.6; ENSP00000433474.1; ENSG00000175274.19.
DR Ensembl; ENST00000533940.5; ENSP00000436152.1; ENSG00000175274.19.
DR Ensembl; ENST00000616990.4; ENSP00000481456.1; ENSG00000175274.19.
DR GeneID; 9537; -.
DR KEGG; hsa:9537; -.
DR MANE-Select; ENST00000525680.6; ENSP00000433474.1; NM_006034.5; NP_006025.2.
DR UCSC; uc001myi.5; human.
DR CTD; 9537; -.
DR DisGeNET; 9537; -.
DR GeneCards; TP53I11; -.
DR HGNC; HGNC:16842; TP53I11.
DR HPA; ENSG00000175274; Low tissue specificity.
DR MIM; 617867; gene.
DR neXtProt; NX_O14683; -.
DR OpenTargets; ENSG00000175274; -.
DR PharmGKB; PA134967898; -.
DR VEuPathDB; HostDB:ENSG00000175274; -.
DR eggNOG; ENOG502QQ2K; Eukaryota.
DR GeneTree; ENSGT00390000017249; -.
DR InParanoid; O14683; -.
DR OMA; VQFVVVT; -.
DR OrthoDB; 1573043at2759; -.
DR PhylomeDB; O14683; -.
DR TreeFam; TF321310; -.
DR PathwayCommons; O14683; -.
DR SignaLink; O14683; -.
DR BioGRID-ORCS; 9537; 16 hits in 1075 CRISPR screens.
DR ChiTaRS; TP53I11; human.
DR GeneWiki; TP53I11; -.
DR GenomeRNAi; 9537; -.
DR Pharos; O14683; Tbio.
DR PRO; PR:O14683; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O14683; protein.
DR Bgee; ENSG00000175274; Expressed in cortical plate and 146 other tissues.
DR ExpressionAtlas; O14683; baseline and differential.
DR Genevisible; O14683; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ProtInc.
DR InterPro; IPR028266; TP53I11.
DR PANTHER; PTHR31584; PTHR31584; 1.
DR Pfam; PF14936; p53-inducible11; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..189
FT /note="Tumor protein p53-inducible protein 11"
FT /id="PRO_0000058142"
FT TOPO_DOM 1..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692"
SQ SEQUENCE 189 AA; 21054 MW; 5E858F5872FE3171 CRC64;
MAAKQPPPLM KKHSQTDLVS RLKTRKILGV GGEDDDGEVH RSKISQVLGN EIKFTIREPL
GLRVWQFVSA VLFSGIAIMA LAFPDQLYDA VFDGAQVTSK TPIRLYGGAL LSISLIMWNA
LYTAEKVIIR WTLLTEACYF GVQFLVVTAT LAETGLMSLG ILLLLVSRLL FVVISIYYYY
QVGRRPKKA
