P5I13_HUMAN
ID P5I13_HUMAN Reviewed; 393 AA.
AC Q8NBR0; Q7L5U3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Tumor protein p53-inducible protein 13;
DE AltName: Full=Damage-stimulated cytoplasmic protein 1;
DE Flags: Precursor;
GN Name=TP53I13; Synonyms=DSCP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC TISSUE=Fetal brain;
RX PubMed=14767535;
RA Hata T., Ogawa T., Yokoyama T.A., Fukushige S., Horii A., Furukawa T.;
RT "DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic
RT stresses and its overexpression inhibits tumor cell growth in vitro.";
RL Int. J. Oncol. 24:513-520(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a tumor suppressor. Inhibits tumor cell growth,
CC when overexpressed. {ECO:0000269|PubMed:14767535}.
CC -!- INTERACTION:
CC Q8NBR0; Q9P2G9-2: KLHL8; NbExp=3; IntAct=EBI-11992976, EBI-11959635;
CC Q8NBR0; Q9C029: TRIM7; NbExp=3; IntAct=EBI-11992976, EBI-2813981;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.
CC Cytoplasm {ECO:0000269|PubMed:14767535}. Note=Associates with unknown
CC subcellular structures in the cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed in heart, placenta, skeletal muscle,
CC testis, brain and lung.
CC -!- INDUCTION: Up-regulated by genotoxic stresses of adriamycin and/or UV
CC irradiation in a p53/TP53-dependent manner.
CC {ECO:0000269|PubMed:14767535}.
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DR EMBL; AB110209; BAD08203.1; -; mRNA.
DR EMBL; AK075341; BAC11555.1; -; mRNA.
DR EMBL; AB110214; BAD08208.1; -; Genomic_DNA.
DR EMBL; CH471159; EAW51192.1; -; Genomic_DNA.
DR EMBL; BC001593; AAH01593.3; -; mRNA.
DR CCDS; CCDS42289.1; -.
DR RefSeq; NP_612358.3; NM_138349.3.
DR AlphaFoldDB; Q8NBR0; -.
DR BioGRID; 124689; 5.
DR IntAct; Q8NBR0; 3.
DR STRING; 9606.ENSP00000301057; -.
DR iPTMnet; Q8NBR0; -.
DR PhosphoSitePlus; Q8NBR0; -.
DR BioMuta; TP53I13; -.
DR DMDM; 74715096; -.
DR jPOST; Q8NBR0; -.
DR MassIVE; Q8NBR0; -.
DR PaxDb; Q8NBR0; -.
DR PeptideAtlas; Q8NBR0; -.
DR PRIDE; Q8NBR0; -.
DR ProteomicsDB; 72811; -.
DR Antibodypedia; 26724; 74 antibodies from 15 providers.
DR DNASU; 90313; -.
DR Ensembl; ENST00000301057.8; ENSP00000301057.7; ENSG00000167543.16.
DR GeneID; 90313; -.
DR KEGG; hsa:90313; -.
DR MANE-Select; ENST00000301057.8; ENSP00000301057.7; NM_138349.4; NP_612358.3.
DR UCSC; uc002hee.4; human.
DR CTD; 90313; -.
DR DisGeNET; 90313; -.
DR GeneCards; TP53I13; -.
DR HGNC; HGNC:25102; TP53I13.
DR HPA; ENSG00000167543; Low tissue specificity.
DR neXtProt; NX_Q8NBR0; -.
DR OpenTargets; ENSG00000167543; -.
DR PharmGKB; PA143485659; -.
DR VEuPathDB; HostDB:ENSG00000167543; -.
DR eggNOG; ENOG502S8FW; Eukaryota.
DR GeneTree; ENSGT00390000008202; -.
DR HOGENOM; CLU_058647_0_0_1; -.
DR InParanoid; Q8NBR0; -.
DR OMA; WGMALEM; -.
DR OrthoDB; 1173676at2759; -.
DR PhylomeDB; Q8NBR0; -.
DR TreeFam; TF314247; -.
DR PathwayCommons; Q8NBR0; -.
DR SignaLink; Q8NBR0; -.
DR BioGRID-ORCS; 90313; 10 hits in 1072 CRISPR screens.
DR ChiTaRS; TP53I13; human.
DR GenomeRNAi; 90313; -.
DR Pharos; Q8NBR0; Tdark.
DR PRO; PR:Q8NBR0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8NBR0; protein.
DR Bgee; ENSG00000167543; Expressed in granulocyte and 152 other tissues.
DR ExpressionAtlas; Q8NBR0; baseline and differential.
DR Genevisible; Q8NBR0; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:UniProtKB.
DR GO; GO:0009411; P:response to UV; IEP:UniProtKB.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:UniProtKB.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..393
FT /note="Tumor protein p53-inducible protein 13"
FT /id="PRO_0000333824"
FT TOPO_DOM 28..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..393
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 184..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 42238 MW; 3BA83E3D28E53C8F CRC64;
MAPPPPSPQL LLLAALARLL GPSEVMAGPA EEAGAHCPES LWPLPPQVSP RVTYTRVSPG
QAEDVTFLYH PCAHPWLKLQ LALLAYACMA NPSLTPDFSL TQDRPLVLTA WGLALEMAWV
EPAWAAHWLM RRRRRKQRKK KAWIYCESLS GPAPSEPTPG RGRLCRRGCV QALALAFALR
SWRPPGTEVT SQGPRQPSSS GAKRRRLRAA LGPQPTRSAL RFPSASPGSL KAKQSMAGIP
GRESNAPSVP TVSLLPGAPG GNASSRTEAQ VPNGQGSPGG CVCSSQASPA PRAAAPPRAA
RGPTPRTEEA AWAAMALTFL LVLLTLATLC TRLHRNFRRG ESIYWGPTAD SQDTVAAVLK
RRLLQPSRRV KRSRRRPLLP PTPDSGPEGE SSE
