ID   P5I13_MOUSE             Reviewed;         385 AA.
AC   Q5F267;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Tumor protein p53-inducible protein 13;
DE   Flags: Precursor;
GN   Name=Tp53i13; Synonyms=Trp53i13;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: May act as a tumor suppressor. Inhibits tumor cell growth,
CC       when overexpressed (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.
CC       Cytoplasm {ECO:0000250}. Note=Associates with unknown subcellular
CC       structures in the cytoplasm. {ECO:0000250}.
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DR   EMBL; AL591136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL607072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL645588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS25081.1; -.
DR   RefSeq; NP_001020091.1; NM_001024920.1.
DR   AlphaFoldDB; Q5F267; -.
DR   STRING; 10090.ENSMUSP00000057592; -.
DR   iPTMnet; Q5F267; -.
DR   PhosphoSitePlus; Q5F267; -.
DR   PaxDb; Q5F267; -.
DR   PRIDE; Q5F267; -.
DR   ProteomicsDB; 294306; -.
DR   Antibodypedia; 26724; 74 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000060417; ENSMUSP00000057592; ENSMUSG00000044328.
DR   GeneID; 216964; -.
DR   KEGG; mmu:216964; -.
DR   UCSC; uc007kgz.1; mouse.
DR   CTD; 216964; -.
DR   MGI; MGI:1915125; Trp53i13.
DR   VEuPathDB; HostDB:ENSMUSG00000044328; -.
DR   eggNOG; ENOG502S8FW; Eukaryota.
DR   GeneTree; ENSGT00390000008202; -.
DR   HOGENOM; CLU_058647_0_0_1; -.
DR   InParanoid; Q5F267; -.
DR   OMA; WGMALEM; -.
DR   OrthoDB; 1173676at2759; -.
DR   PhylomeDB; Q5F267; -.
DR   TreeFam; TF314247; -.
DR   BioGRID-ORCS; 216964; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Trp53i13; mouse.
DR   PRO; PR:Q5F267; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q5F267; protein.
DR   Bgee; ENSMUSG00000044328; Expressed in ankle joint and 193 other tissues.
DR   ExpressionAtlas; Q5F267; baseline and differential.
DR   Genevisible; Q5F267; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISO:MGI.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..385
FT                   /note="Tumor protein p53-inducible protein 13"
FT                   /id="PRO_0000333825"
FT   TOPO_DOM        28..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..385
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          242..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  41766 MW;  BDBBF29BE2439182 CRC64;
     MVHPPPPPPR LLLVALVGLL SLREVVAEPA EEAGTPCPEG LWPVPPQVLP RVTYTQVSQG
     QAEGIAFFYH PCAHPWLKLQ LALLAHLYVA KPTLIPDFSL TWDRPLVLTA WGTALELAWI
     EPAWVAHWLK RQRRRKQRKS VWFLSDNLFG PTPTMPASRR GKLCGRRCVQ APTLAFALRS
     WRPPGAQVTS RGSGRSSISV VKRRGLRAAL GLQSTPPGLR VSLASSQSLK AQQLTLGTSS
     VAPVSLTTGG PGGNGRSRTE AQMPSGQGNH GGCACPGQVS PAPRAAGPPR VARGPTPRTE
     EAAWAAMALT FLLVLLTLAT LCTRLHRNFR RSESIYWGPT ADSQDTVAAL LKRRLPLPSR
     RIKRSRRRPL LPPTPDSGPD SESSD