ID   P5I13_RAT               Reviewed;         388 AA.
AC   B0BN44;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Tumor protein p53-inducible protein 13;
DE   Flags: Precursor;
GN   Name=Tp53i13; Synonyms=Trp53i13;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as a tumor suppressor. Inhibits tumor cell growth,
CC       when overexpressed (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.
CC       Cytoplasm {ECO:0000250}. Note=Associates with unknown subcellular
CC       structures in the cytoplasm. {ECO:0000250}.
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DR   EMBL; BC158678; AAI58679.1; -; mRNA.
DR   RefSeq; NP_001099288.1; NM_001105818.1.
DR   AlphaFoldDB; B0BN44; -.
DR   STRING; 10116.ENSRNOP00000010691; -.
DR   PhosphoSitePlus; B0BN44; -.
DR   PaxDb; B0BN44; -.
DR   PRIDE; B0BN44; -.
DR   Ensembl; ENSRNOT00000010691; ENSRNOP00000010691; ENSRNOG00000022615.
DR   GeneID; 287550; -.
DR   KEGG; rno:287550; -.
DR   CTD; 90313; -.
DR   RGD; 1559818; Tp53i13.
DR   eggNOG; ENOG502S8FW; Eukaryota.
DR   GeneTree; ENSGT00390000008202; -.
DR   HOGENOM; CLU_058647_0_0_1; -.
DR   InParanoid; B0BN44; -.
DR   OMA; WGMALEM; -.
DR   OrthoDB; 1173676at2759; -.
DR   PhylomeDB; B0BN44; -.
DR   TreeFam; TF314247; -.
DR   PRO; PR:B0BN44; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000022615; Expressed in pancreas and 19 other tissues.
DR   Genevisible; B0BN44; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISO:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; ISO:RGD.
DR   GO; GO:0009411; P:response to UV; ISO:RGD.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; ISO:RGD.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..388
FT                   /note="Tumor protein p53-inducible protein 13"
FT                   /id="PRO_0000333826"
FT   TOPO_DOM        28..304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..388
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          361..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  42710 MW;  8FE970A47D13F97F CRC64;
     MVPPPPPPSR LLLVALVGLL SLHEVVAEPA EEAGTRCPEG LWPLPPQVLP RVTYTQVRQG
     QAEGITFFYH PCAHLWLKLQ LAVLAHLCVA KPTLIPDFSL PWDRPLVLTA WGTALEMAWI
     EPAWAAQWLK RQWRRRRRKQ RKSVWFLSDN LFGPTPMMPA PRRGKLCGRR CVQAPTLAFA
     LRSWRPPGVE VTSRGPRRSS LSVVKKRGLR AALGLQSTPS GLRVSLASSQ SLKAQQRTLG
     NSSVAPVSLM TGVTEGNGRF RTEAQMPSGQ GNPGGCACPG QVSPAPRAAV PPRVARGPTP
     RTEEAAWAAM ALTFLLVLLT LATLCTRLHR NFRRSESIYW GPTSDSQDTV AAILKRRLPL
     PSRRIKRSRR RPLLPPTPDS GPDSESSD