ID   P69_TYMV                Reviewed;         628 AA.
AC   P10357;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   02-JUN-2021, entry version 55.
DE   RecName: Full=69 kDa protein;
DE   AltName: Full=p69;
OS   Turnip yellow mosaic virus.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Tymoviridae; Tymovirus.
OX   NCBI_TaxID=12154;
OH   NCBI_TaxID=3705; Brassica.
OH   NCBI_TaxID=51351; Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis).
OH   NCBI_TaxID=82359; Cardamine lilacina.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3399388; DOI=10.1093/nar/16.13.6157;
RA   Morch M.D., Boyer J.C., Haenni A.L.;
RT   "Overlapping open reading frames revealed by complete nucleotide sequencing
RT   of turnip yellow mosaic virus genomic RNA.";
RL   Nucleic Acids Res. 16:6157-6173(1988).
RN   [2]
RP   FUNCTION.
RC   STRAIN=Blue Lake;
RX   PubMed=15100397; DOI=10.1105/tpc.018986;
RA   Chen J., Li W.X., Xie D., Peng J.R., Ding S.W.;
RT   "Viral virulence protein suppresses RNA silencing-mediated defense but
RT   upregulates the role of microrna in host gene expression.";
RL   Plant Cell 16:1302-1313(2004).
CC   -!- FUNCTION: Acts as a suppressor of RNA-mediated gene silencing, also
CC       known as post-transcriptional gene silencing (PTGS), a mechanism of
CC       plant viral defense that limits the accumulation of viral RNAs.
CC       {ECO:0000269|PubMed:15100397}.
CC   -!- SIMILARITY: Belongs to the tymoviridae protein p69 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X07441; CAA30321.1; ALT_SEQ; Genomic_RNA.
DR   PIR; S01955; S01955.
DR   RefSeq; NP_663296.1; NC_004063.1.
DR   GeneID; 951156; -.
DR   KEGG; vg:951156; -.
DR   Proteomes; UP000000401; Genome.
DR   InterPro; IPR004935; 45/70kDa_tymovirus.
DR   Pfam; PF03251; Tymo_45kd_70kd; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Suppressor of RNA silencing.
FT   CHAIN           1..628
FT                   /note="69 kDa protein"
FT                   /id="PRO_0000222943"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          535..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..202
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..239
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..262
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..450
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..557
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..614
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  69195 MW;  9B01CE5ADFCEAC77 CRC64;
     MSNGLPISIG RPCTHDSQRS LSAPDSRIHS GFNSLLDTDL PMVHSEGTST PTQLLRHPNI
     WFGNLPPPPR RPQDNRDFSP LHPLVFPGHH SQLRHVHETQ QVQQTCPGKL KLSGAEELPP
     APQRQHSLPL HITRPSRFPH HFHARRPDVL PSVPDHGPVL TETKPRTSVR QPRSATRGPS
     FRPILLPKVV HVHDDPPHSS LRPRGSRSRQ LQPTVRRPLL APNQFHSPRQ PPPLSDDPGI
     LGPRPLAPHS TRDPPPRPIT PGPSNTHDLR PLSVLPRTSP RRGLLPNPRR HRTSTGHIPP
     TTTSRPTGPP SRLQRPVHLY QSSPHTPNFR PSSIRKDALL QTGPRLGHLE RLGQPANLRT
     SERSPPTKRR LPRSSEPNRL PKPLPEATLA PSYRHRRPYP LLPNPPAALP SIAYTSSRGK
     IHHSLPKGAL PKEGAPPPPR RLPSPAPRPQ LPLRDLGRTP GFPTPPKTPT RTPESRITAS
     PTDIAPLDSD PVLSVRTEVH APERRTFMDP EALRSALASL PSPPRSVGII HTAPQTVLPA
     NPPSPTRHLP PTSPPWILQS PVGEDAIVDS EDDSISSFHS HDFDSPSGPL RSQSPSRFRL
     HLRSPSTSSG IEPWSPASYD YGSAPDTD