ID   P72_MYCMS               Reviewed;         532 AA.
AC   P55801;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Immunodominant protein p72;
DE   Flags: Precursor;
GN   Name=p72; OrderedLocusNames=MSC_0014;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L2;
RX   PubMed=9004514; DOI=10.1099/13500872-142-12-3515;
RA   Cheng X., Nicolet J., Miserez R., Kuhnert P., Krampe M., Pilloud T.,
RA   Abdo E.-M., Griot C., Frey J.;
RT   "Characterization of the gene for an immunodominant 72 kDa lipoprotein of
RT   Mycoplasma mycoides subsp. mycoides small colony type.";
RL   Microbiology 142:3515-3524(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT   PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- FUNCTION: May play a role in virulence.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycoplasma p72 lipoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; U61140; AAC44571.1; -; Genomic_DNA.
DR   EMBL; U53210; AAC44569.1; -; Genomic_DNA.
DR   EMBL; BX293980; CAE76667.1; -; Genomic_DNA.
DR   RefSeq; NP_975025.1; NC_005364.2.
DR   AlphaFoldDB; P55801; -.
DR   STRING; 272632.MSC_0014; -.
DR   EnsemblBacteria; CAE76667; CAE76667; MSC_0014.
DR   KEGG; mmy:MSC_0014; -.
DR   PATRIC; fig|272632.4.peg.14; -.
DR   eggNOG; ENOG5031YVH; Bacteria.
DR   HOGENOM; CLU_030565_0_0_14; -.
DR   OMA; HTRITKD; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019992; Mycoides_lipoprot_LppA/p72.
DR   TIGRFAMs; TIGR03490; Mycoplas_LppA; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal; Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           25..532
FT                   /note="Immunodominant protein p72"
FT                   /id="PRO_0000018099"
FT   REGION          26..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           25
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           25
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        473
FT                   /note="S -> L (in Ref. 1; AAC44571/AAC44569)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   532 AA;  61092 MW;  33F4702219F777E0 CRC64;
     MKKATKLLLS ILPISSISFL SVVSCSTRNS NAKQPDKKPE KPNENTPKTP SKPDESKQPD
     NNNTNPGDSN NGSNNPEIKP DPSENPQSDQ PMDKPDEKID KPSHSDKPQA DDSNNNRDIF
     SDLDKISKEI SFETFSFYTQ RDAVTALVDL QKDPSTIYTI FSKDYKTIFD KYHIQFLANN
     EESANNEKGL IEKVKLKFTH KKFDQSKILD FIFTGFKKNE YTSITNNKEK YITKREKVEK
     ITDLFPSLIG YVLLYSQDHN QYKNLMEAKN VINFEDLENG NSSLFIDKAP LLNVATIKDY
     LFEFNPELGK LYKEKITAVK YDDYNGILGV KLEIENRDFD PKTTKEPIIE KEFVFDNFRK
     VNIKDNEKNP LSLFLTQDKF KEMTKSGLLK TKIQELRSSN KLEKKELLQD KKIDFLKQQI
     FKNLLVDIND NSHNIYRSQS TLSLGSNKTY KSILGLAGGF SIYPFHTSIN KDSIKNIYLS
     INKDEENVHK AIIEFEVYIP VFSTGFSDLK SYATSGDEKY LVLKIVQTTS IQ