P78_NPVAC
ID P78_NPVAC Reviewed; 543 AA.
AC Q03209;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 29-SEP-2021, entry version 68.
DE RecName: Full=Protein P78/83;
GN Name=P61; ORFNames=ORF9;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=E2;
RX PubMed=1487149; DOI=10.1016/0378-1119(92)90224-d;
RA Pham D.Q.-D., Sivasubramanian N.;
RT "Sequence and in vitro translational analysis of a 1629-nucleotide ORF in
RT Autographa californica nuclear polyhedrosis virus strain E2.";
RL Gene 122:345-348(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=1926775; DOI=10.1016/0042-6822(91)90770-c;
RA Possee R.D., Sun T.P., Howard S.C., Ayres M.D., Hill-Perkins M.,
RA Gearing K.L.;
RT "Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4
RT kbp EcoRI-I and -R (polyhedrin gene) region.";
RL Virology 185:229-241(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [4]
RP INTERACTION WITH C42 AND E27.
RX PubMed=11711623; DOI=10.1128/jvi.75.24.12331-12338.2001;
RA Braunagel S.C., Guidry P.A., Rosas-Acosta G., Engelking L., Summers M.D.;
RT "Identification of BV/ODV-C42, an Autographa californica
RT nucleopolyhedrovirus orf101-encoded structural protein detected in
RT infected-cell complexes with ODV-EC27 and p78/83.";
RL J. Virol. 75:12331-12338(2001).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST ARP2/3.
RX PubMed=17053146; DOI=10.1126/science.1133348;
RA Goley E.D., Ohkawa T., Mancuso J., Woodruff J.B., D'Alessio J.A.,
RA Cande W.Z., Volkman L.E., Welch M.D.;
RT "Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-
RT like protein.";
RL Science 314:464-467(2006).
RN [6]
RP FUNCTION.
RX PubMed=20660627; DOI=10.1083/jcb.201001162;
RA Ohkawa T., Volkman L.E., Welch M.D.;
RT "Actin-based motility drives baculovirus transit to the nucleus and cell
RT surface.";
RL J. Cell Biol. 190:187-195(2010).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH PROTEIN AC102.
RX PubMed=29540600; DOI=10.1128/jvi.00111-18;
RA Hepp S.E., Borgo G.M., Ticau S., Ohkawa T., Welch M.D.;
RT "Baculovirus AC102 is a nucleocapsid protein that is crucial for nuclear
RT actin polymerization and nucleocapsid morphogenesis.";
RL J. Virol. 0:0-0(2018).
CC -!- FUNCTION: Plays a role in the transport of the nucleocapsids from the
CC cytoplasm toward the host nucleus together with the host actin-
CC polymerizing Arp2/3 complex. {ECO:0000269|PubMed:17053146,
CC ECO:0000269|PubMed:20660627}.
CC -!- SUBUNIT: Forms a complex with proteins C42 and E27. Interacts with host
CC actin-related protein 2/3 complex. Interacts with protein Ac102.
CC {ECO:0000269|PubMed:11711623, ECO:0000269|PubMed:17053146}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:17053146}.
CC Host nucleus {ECO:0000269|PubMed:17053146}.
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DR EMBL; Z11662; CAA77730.1; -; Genomic_DNA.
DR EMBL; M75679; AAA46705.1; -; Genomic_DNA.
DR EMBL; L22858; AAA66639.1; -; Genomic_DNA.
DR PIR; S25128; S25128.
DR RefSeq; NP_054038.1; NC_001623.1.
DR GeneID; 1403841; -.
DR KEGG; vg:1403841; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0075520; P:actin-dependent intracellular transport of virus; IDA:UniProtKB.
DR InterPro; IPR003124; WH2_dom.
DR PROSITE; PS51082; WH2; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host nucleus; Reference proteome.
FT CHAIN 1..543
FT /note="Protein P78/83"
FT /id="PRO_0000132912"
FT DOMAIN 226..246
FT /note="WH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00406"
FT REGION 147..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..220
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..319
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 361
FT /note="V -> A (in Ref. 1; CAA77730)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 543 AA; 60714 MW; 196D295D5E5FC100 CRC64;
MTNRRYESVQ SYLFNNRNNK IDAHQFFERV DTAEAQIIKN NIYDNTVVLN RDVLLNILKL
ANDVFDNKAY MYVDDSEVSR HYNAVVKMKR LVIGVRDPSL RQSLYNTIAY IERLLNIGTV
NDSEITMLIA DFYDLYSNYN IELPPPQALP RSRRPSVVQP AAPAPVPTIV REQTKPEQII
PAAPPPPPSP VPNIPAPPPP PPPSMSELPP APPMPTEPQP AAPLDDRQQL LEAIRNEKNR
TRLRPVKPKT APETSTIVEV PTVLPKETFE PKPPSASPPP PPPPPPPPAP PAPPPMVDLS
SAPPPPPLVD LPSEMLPPPA PSLSNVLSEL KSGTVRLKPA QKRPQSEIIP KSSTTNLIAD
VLADTINRRR VAMAKSSSEA TSNDEGWDDD DNRPNKANTP DVKYVQALFN VFTSSQLYTN
DSDERNTKAH NILNDVEPLL QNKTQTNIDK ARLLLQDLAS FVALSENPLD SPAIGSEKQP
LFETNRNLFY KSIEDLIFKF RYKDAENHLI FALTYHPKDY KFNELLKYVQ QLSVNQQRTE
SSA
