ID   P7_ISAV8                Reviewed;         183 AA.
AC   Q8V3U3;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   02-JUN-2021, entry version 35.
DE   RecName: Full=Protein P7;
DE            Short=P7;
GN   Name=Segment-8 {ECO:0000303|PubMed:20979983}; ORFNames=s8ORF2;
OS   Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)
OS   (ISAV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=652965;
OH   NCBI_TaxID=8049; Gadus morhua (Atlantic cod).
OH   NCBI_TaxID=8019; Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8060; Pollachius virens (Saithe) (Gadus virens).
OH   NCBI_TaxID=8030; Salmo salar (Atlantic salmon).
OH   NCBI_TaxID=8032; Salmo trutta (Brown trout).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11807235; DOI=10.1099/0022-1317-83-2-421;
RA   Clouthier S.C., Rector T., Brown N.E., Anderson E.D.;
RT   "Genomic organization of infectious salmon anaemia virus.";
RL   J. Gen. Virol. 83:421-428(2002).
RN   [2]
RP   REVIEW.
RX   PubMed=20979983; DOI=10.1016/j.virusres.2010.10.021;
RA   Cottet L., Rivas-Aravena A., Cortez-San Martin M., Sandino A.M.,
RA   Spencer E.;
RT   "Infectious salmon anemia virus--genetics and pathogenesis.";
RL   Virus Res. 155:10-19(2011).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=27012395; DOI=10.1016/j.fsi.2016.03.038;
RA   Li C., Greiner-Tollersrud L., Robertsen B.;
RT   "Infectious salmon anemia virus segment 7 ORF1 and segment 8 ORF2 proteins
RT   inhibit IRF mediated activation of the Atlantic salmon IFNa1 promoter.";
RL   Fish Shellfish Immunol. 52:258-262(2016).
CC   -!- FUNCTION: May play a role in inhibition of the host immune system by
CC       counteracting the type I interferon response.
CC       {ECO:0000269|PubMed:27012395}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:27012395}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Matrix protein 2;
CC         IsoId=Q8V3U3-1; Sequence=Displayed;
CC       Name=Matrix protein 1;
CC         IsoId=Q8V3U4-1; Sequence=External;
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DR   EMBL; AF404340; AAL67955.1; -; Genomic_RNA.
DR   RefSeq; YP_145797.1; NC_006497.1.
DR   SMR; Q8V3U3; -.
DR   GeneID; 5075848; -.
DR   KEGG; vg:5075848; -.
DR   Proteomes; UP000008772; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Alternative splicing; Host nucleus; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..183
FT                   /note="Protein P7"
FT                   /id="PRO_0000403925"
SQ   SEQUENCE   183 AA;  20340 MW;  7FE092EDC900FA6B CRC64;
     MREANPKPRE LIRHALKKKK RPEVVYAMGV LLTLGGESGL TVEFPVPEGK TVKVKTLNQL
     VNGMISRATM TLYCVMKDPP SGGMATLMRD HIRNWLKEES GCQDADGGEE KWAMVYGMIS
     PDMAEEKTML KELKTMLHSR MQMYALGASS KALENLEKAI VAAVHRLPAS CSTEKMVLLG
     YLK