ID   P80_DICDI               Reviewed;         530 AA.
AC   Q7YXD4; Q54KI5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein P80;
DE   AltName: Full=Endosomal membrane protein;
DE   Flags: Precursor;
GN   Name=p80; ORFNames=DDB_G0287297;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, AND SUBCELLULAR LOCATION.
RC   STRAIN=AX3 / DH1;
RX   PubMed=11831389; DOI=10.1078/0171-9335-00215;
RA   Ravanel K., de Chassey B., Cornillon S., Benghezal M., Zulianello L.,
RA   Gebbie L., Letourneur F., Cosson P.;
RT   "Membrane sorting in the endocytic and phagocytic pathway of Dictyostelium
RT   discoideum.";
RL   Eur. J. Cell Biol. 80:754-764(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000269|PubMed:11831389}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:11831389}.
CC   -!- DOMAIN: The cytoplasmic domain (residues 431-481) is responsible for
CC       the endocytosis and localization of the protein to endocytic
CC       compartments. {ECO:0000269|PubMed:11831389}.
CC   -!- SIMILARITY: Belongs to the SLC31A transporter family. {ECO:0000305}.
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DR   EMBL; AJ315489; CAC86573.1; -; mRNA.
DR   EMBL; AAFI02000100; EAL63716.2; -; Genomic_DNA.
DR   RefSeq; XP_637238.2; XM_632146.2.
DR   AlphaFoldDB; Q7YXD4; -.
DR   SMR; Q7YXD4; -.
DR   STRING; 44689.DDB0191340; -.
DR   PaxDb; Q7YXD4; -.
DR   ABCD; Q7YXD4; 2 sequenced antibodies.
DR   EnsemblProtists; EAL63716; EAL63716; DDB_G0287297.
DR   GeneID; 8626069; -.
DR   KEGG; ddi:DDB_G0287297; -.
DR   dictyBase; DDB_G0287297; p80.
DR   eggNOG; KOG3386; Eukaryota.
DR   HOGENOM; CLU_453728_0_0_1; -.
DR   InParanoid; Q7YXD4; -.
DR   PhylomeDB; Q7YXD4; -.
DR   PRO; PR:Q7YXD4; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0009986; C:cell surface; IDA:dictyBase.
DR   GO; GO:0030666; C:endocytic vesicle membrane; IDA:dictyBase.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:dictyBase.
DR   GO; GO:0005770; C:late endosome; IDA:dictyBase.
DR   GO; GO:0031902; C:late endosome membrane; IDA:dictyBase.
DR   GO; GO:0044354; C:macropinosome; IDA:dictyBase.
DR   GO; GO:0001891; C:phagocytic cup; IDA:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0009617; P:response to bacterium; IDA:dictyBase.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 1.
PE   2: Evidence at transcript level;
KW   Endocytosis; Endosome; Membrane; Phagocytosis; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..530
FT                   /note="Protein P80"
FT                   /id="PRO_0000328631"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   530 AA;  57633 MW;  5F35B207C830CC61 CRC64;
     MKVISGLLFF ILISCSLFLV QGQVDCVTNS SDASCTNFQY PLANITADIN NLCGSMPYMP
     VCTIQQSCNQ ESSTSGICDP FSILGDSCLH DMPGMSGCNN FKKLCASGSV VEQCSTVDSV
     TDLPTTMKMW ANIKSICNEM TMTGCEKCTI LNATCDVLTV YSTLCLAMPE MGQCANWTQM
     CASSGNMASS PISSGICTDE PTPATDCFTN PSDPSCADYV YTAANANADI LNLCKSMPYM
     TVCSIQKSCN QESSTSGICA PFSILGDSCL HDMPGMNGCS NFKKLCASGS VVEQCSSVDS
     ISNLPTTMQL FAGIKSICTE MAMDGCEKCS GNSPTTTCDV LPVYSSLCMA MPDMSQCANW
     TKMCSSSGQL YNSQITSDYC VASVADAVPI MRMYFHTGIL DYILFKSWVP RTDRQFAGSW
     FAIFFFAIFF ELEKTLRSIL EKRWTPNKKD SEDNNLINSS FLSGSYPKFS YRDIIRGCLH
     AIELTCSYAL MLVAMTFNVA LFFAVIAGVL VGNILFGRYR NYTPRVTCCE