PA1B2_DROME
ID PA1B2_DROME Reviewed; 225 AA.
AC Q9VXP4; A4V4G6; O96644;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Platelet-activating factor acetylhydrolase IB subunit beta homolog;
GN Name=Paf-AHalpha; ORFNames=CG8962;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], LACK OF ENZYME ACTIVITY, AND LACK OF
RP INTERACTION WITH LIS-1.
RX PubMed=10737922;
RX DOI=10.1002/(sici)1097-0134(20000401)39:1<1::aid-prot1>3.0.co;2-n;
RA Sheffield P.J., Garrard S., Caspi M., Aoki J., Arai H., Derewenda U.,
RA Inoue K., Suter B., Reiner O., Derewenda Z.S.;
RT "Homologs of the alpha- and beta-subunits of mammalian brain platelet-
RT activating factor acetylhydrolase Ib in the Drosophila melanogaster
RT genome.";
RL Proteins 39:1-8(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBUNIT: Does not interact with Lis-1.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family. Platelet-
CC activating factor acetylhydrolase IB beta/gamma subunits subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Although strongly related to acetylglycerophosphocholine
CC esterase enzymes, it lacks the active site and has no lipase activity.
CC {ECO:0000305}.
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DR EMBL; AF098069; AAC83820.1; -; mRNA.
DR EMBL; AE014298; AAF48514.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09364.1; -; Genomic_DNA.
DR EMBL; AY069389; AAL39534.1; -; mRNA.
DR RefSeq; NP_525089.2; NM_080350.4.
DR RefSeq; NP_727895.1; NM_167461.2.
DR AlphaFoldDB; Q9VXP4; -.
DR SMR; Q9VXP4; -.
DR BioGRID; 58877; 1.
DR IntAct; Q9VXP4; 5.
DR STRING; 7227.FBpp0073975; -.
DR PaxDb; Q9VXP4; -.
DR PRIDE; Q9VXP4; -.
DR DNASU; 32529; -.
DR EnsemblMetazoa; FBtr0074190; FBpp0073975; FBgn0025809.
DR EnsemblMetazoa; FBtr0074191; FBpp0073976; FBgn0025809.
DR GeneID; 32529; -.
DR KEGG; dme:Dmel_CG8962; -.
DR CTD; 32529; -.
DR FlyBase; FBgn0025809; Paf-AHalpha.
DR VEuPathDB; VectorBase:FBgn0025809; -.
DR eggNOG; KOG1388; Eukaryota.
DR GeneTree; ENSGT00950000183199; -.
DR HOGENOM; CLU_051989_2_0_1; -.
DR InParanoid; Q9VXP4; -.
DR OMA; NHAISCH; -.
DR OrthoDB; 1604899at2759; -.
DR PhylomeDB; Q9VXP4; -.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 32529; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Paf-AHalpha; fly.
DR GenomeRNAi; 32529; -.
DR PRO; PR:Q9VXP4; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0025809; Expressed in cleaving embryo and 22 other tissues.
DR Genevisible; Q9VXP4; DM.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..225
FT /note="Platelet-activating factor acetylhydrolase IB
FT subunit beta homolog"
FT /id="PRO_0000058150"
FT CONFLICT 2
FT /note="N -> D (in Ref. 1; AAC83820)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="Y -> C (in Ref. 1; AAC83820)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 25461 MW; 0132B3A6D4AD7A7C CRC64;
MNPCVLPTPL PDLDGDKRWH SIHRRFISDC REKDPDVIFL GDCIFETVQD TEAWNKYFAP
LHCLNFSIRD DCTEHVLWRI ENGALDNVNP KIVVLHVGTN NVRNSAEEVA EGVLANVTKI
RQKLPNAYIV LPSLLPRGQQ PNKLREKNAK INEVVNGLTK GLYRVQTVAI DKGLVQTDGS
ISHHDMFDYK NLTNAGAKKI LEPLYDLLSQ ILNENEPEND LTPSE
