ID   ASIC2_CAEEL             Reviewed;         545 AA.
AC   Q22851;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Degenerin-like protein asic-2;
DE   AltName: Full=Acid-sensing/amiloride-sensitive ion channel protein 2;
GN   Name=asic-2; ORFNames=T28F4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000305}.
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DR   EMBL; Z72517; CAA96693.1; -; Genomic_DNA.
DR   PIR; T25429; T25429.
DR   RefSeq; NP_492099.1; NM_059698.1.
DR   AlphaFoldDB; Q22851; -.
DR   BioGRID; 53709; 1.
DR   STRING; 6239.T28F4.2; -.
DR   PaxDb; Q22851; -.
DR   EnsemblMetazoa; T28F4.2.1; T28F4.2.1; WBGene00012137.
DR   GeneID; 189058; -.
DR   KEGG; cel:CELE_T28F4.2; -.
DR   UCSC; T28F4.2; c. elegans.
DR   CTD; 189058; -.
DR   WormBase; T28F4.2; CE06524; WBGene00012137; asic-2.
DR   eggNOG; KOG4294; Eukaryota.
DR   HOGENOM; CLU_020415_3_1_1; -.
DR   InParanoid; Q22851; -.
DR   OMA; PNIHRSK; -.
DR   OrthoDB; 686369at2759; -.
DR   PhylomeDB; Q22851; -.
DR   PRO; PR:Q22851; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00012137; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690; PTHR11690; 2.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium channel; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..545
FT                   /note="Degenerin-like protein asic-2"
FT                   /id="PRO_0000181313"
FT   TOPO_DOM        1..34
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..457
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        479..545
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          514..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        201
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        350
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   545 AA;  59510 MW;  0285F4A7009C5914 CRC64;
     MRGGGFVQIF KDFSNWSTVA VVPHVANANN KISRIFWIAI FLFVLGMFAY ELYILIAKFF
     SYPATVNTEI LFEKQIFPVV TVCNMNPYKY SVVKSNSAFS SVNTLMTTYS DATVGTFSTD
     KWGLYADNDE TYDLDSRAAD ALVLEANLIS DTAKVPALYT YADLIQDCSF AGIPCSESDF
     TKFIDPVYGA CYSFNEDASL NYSVSREGIQ FGLKLMLTVT QTKTNGNTDS LPTTKLAGAR
     IGVNSRGSSP GLDSNGIDAG VGYESAVSVS LTQNVRAKKP YGTCVDREPD SSDYYKDFIY
     TLETCFNGCK QRDTIAKCQC ANPRLALGST DTACQPIKAD LDCLQTLKGN QTSSTPNIDL
     LVECNCNPPC DESTYTPTVS LAQFPSTSYY VATSSTAGVG SCSSTNSKFS SKSDCQKWYN
     NNGMIIQVFL ETLSYELYTE TAGYTVSNVI NDLGGQAGLW LGLSVISVVE MTGLMLVMGA
     FCVTGGAIKM APDDDEIEND HRIKDVEDVK KEIDHLEKKH GEMESGSDGE VDDIENKGDE
     EKKKK