ASIC4_MOUSE
ID ASIC4_MOUSE Reviewed; 539 AA.
AC Q7TNS7; Q80XK4;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Acid-sensing ion channel 4;
DE Short=ASIC4;
DE AltName: Full=Amiloride-sensitive cation channel 4;
GN Name=Asic4; Synonyms=Accn4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable cation channel with high affinity for sodium.
CC -!- SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- MISCELLANEOUS: In vitro, has no proton-gated channel activity.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC4 subfamily. {ECO:0000305}.
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DR EMBL; BC046481; AAH46481.1; -; mRNA.
DR EMBL; BC055772; AAH55772.1; -; mRNA.
DR CCDS; CCDS15073.1; -.
DR RefSeq; NP_898843.1; NM_183022.3.
DR AlphaFoldDB; Q7TNS7; -.
DR SMR; Q7TNS7; -.
DR STRING; 10090.ENSMUSP00000045598; -.
DR GlyConnect; 2102; 3 N-Linked glycans (2 sites).
DR GlyGen; Q7TNS7; 5 sites, 3 N-linked glycans (2 sites).
DR iPTMnet; Q7TNS7; -.
DR PhosphoSitePlus; Q7TNS7; -.
DR MaxQB; Q7TNS7; -.
DR PaxDb; Q7TNS7; -.
DR PRIDE; Q7TNS7; -.
DR ProteomicsDB; 281847; -.
DR Antibodypedia; 20142; 141 antibodies from 23 providers.
DR DNASU; 241118; -.
DR Ensembl; ENSMUST00000037708; ENSMUSP00000045598; ENSMUSG00000033007.
DR GeneID; 241118; -.
DR KEGG; mmu:241118; -.
DR UCSC; uc007bpg.1; mouse.
DR CTD; 55515; -.
DR MGI; MGI:2652846; Asic4.
DR VEuPathDB; HostDB:ENSMUSG00000033007; -.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000159052; -.
DR InParanoid; Q7TNS7; -.
DR OMA; IHEYCDY; -.
DR OrthoDB; 686369at2759; -.
DR PhylomeDB; Q7TNS7; -.
DR TreeFam; TF330663; -.
DR Reactome; R-MMU-2672351; Stimuli-sensing channels.
DR BioGRID-ORCS; 241118; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q7TNS7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q7TNS7; protein.
DR Bgee; ENSMUSG00000033007; Expressed in roof plate of diencephalon and 92 other tissues.
DR ExpressionAtlas; Q7TNS7; baseline and differential.
DR Genevisible; Q7TNS7; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0001662; P:behavioral fear response; IMP:MGI.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690; PTHR11690; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium channel; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..539
FT /note="Acid-sensing ion channel 4"
FT /id="PRO_0000181305"
FT TOPO_DOM 1..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..438
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..539
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 500..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 341
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 376
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 118..202
FT /evidence="ECO:0000250"
FT DISULFID 180..187
FT /evidence="ECO:0000250"
FT DISULFID 296..375
FT /evidence="ECO:0000250"
FT DISULFID 318..371
FT /evidence="ECO:0000250"
FT DISULFID 322..369
FT /evidence="ECO:0000250"
FT DISULFID 331..353
FT /evidence="ECO:0000250"
FT DISULFID 333..345
FT /evidence="ECO:0000250"
SQ SEQUENCE 539 AA; 59216 MW; 25A4B1E73D67FE9A CRC64;
MPIEIVCKIK FAEEDAKPKE KEAGDEQSLL GAAQGPAAPR DLATFASTST LHGLGRACGP
GPHGLRRTLW ALALLTSLAA FLYQAASLAR GYLTRPHLVA MDPAAPAPVA GFPAVTLCNI
NRFRHSALSD ADIFHLANLT GLPPKDRDGH RAAGLRYPEP DMVDILNRTG HQLADMLKSC
NFSGHHCSAS NFSVVYTRYG KCYTFNADPQ SSLPSRAGGM GSGLEIMLDI QQEEYLPIWR
ETNETSFEAG IRVQIHSQEE PPYIHQLGFG VSPGFQTFVS CQEQRLTYLP QPWGNCRAES
ELREPELQGY SAYSVSACRL RCEKEAVLQR CHCRMVHMPG NETICPPNIY IECADHTLDS
LGGGSEGPCF CPTPCNLTRY GKEISMVKIP NRGSARYLAR KYNRNETYIR ENFLVLDVFF
EALTSEAMEQ QAAYGLSALL GDLGGQMGLF IGASILTLLE ILDYIYEVSW DRLKRVWRRP
KTPLRTSTGG ISTLGLQELK EQSPCPSRGR AEGGGASSLL PNHHHPHGPP GSLFEDFAC
