ASIP_MACNE
ID ASIP_MACNE Reviewed; 132 AA.
AC A1YL69;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Agouti-signaling protein;
DE Short=ASP;
DE AltName: Full=Agouti switch protein;
DE Flags: Precursor;
GN Name=ASIP;
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17143587; DOI=10.1007/s00335-006-0056-0;
RA Mundy N.I., Kelly J.;
RT "Investigation of the role of the agouti signaling protein gene (ASIP) in
RT coat color evolution in primates.";
RL Mamm. Genome 17:1205-1213(2006).
CC -!- FUNCTION: Involved in the regulation of melanogenesis. The binding of
CC ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks
CC production of cAMP, leading to a down-regulation of eumelanogenesis
CC (brown/black pigment) and thus increasing synthesis of pheomelanin
CC (yellow/red pigment) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
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DR EMBL; EF094486; ABL84284.1; -; Genomic_DNA.
DR AlphaFoldDB; A1YL69; -.
DR STRING; 9545.ENSMNEP00000035064; -.
DR Proteomes; UP000233120; Whole Genome Shotgun Assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.760.10; -; 1.
DR InterPro; IPR007733; Agouti.
DR InterPro; IPR027300; Agouti_dom.
DR InterPro; IPR036836; Agouti_dom_sf.
DR PANTHER; PTHR16551; PTHR16551; 1.
DR Pfam; PF05039; Agouti; 1.
DR SMART; SM00792; Agouti; 1.
DR SUPFAM; SSF57055; SSF57055; 1.
DR PROSITE; PS60024; AGOUTI_1; 1.
DR PROSITE; PS51150; AGOUTI_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Knottin; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..132
FT /note="Agouti-signaling protein"
FT /id="PRO_0000285057"
FT DOMAIN 93..132
FT /note="Agouti"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT REGION 61..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 93..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 100..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 107..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 111..132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 116..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
SQ SEQUENCE 132 AA; 14643 MW; 0B55D0E44678EB98 CRC64;
MDVTRLLLAT LLVFLCFFTA YSHPPPEEKL RDDRSLRSNS SVNLLDFPSV SIVALNKNSK
QISRKEAEKK RSSKKEASMK KVARPRTPLS APCVATRDSC KPPAPACCDP CASCQCRFFR
SACSCRVLSL NC