PAAF1_BOVIN
ID PAAF1_BOVIN Reviewed; 392 AA.
AC Q148I1;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Proteasomal ATPase-associated factor 1;
DE AltName: Full=WD repeat-containing protein 71;
GN Name=PAAF1; Synonyms=WDR71;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits proteasome 26S assembly and activity by impairing
CC the association of the 19S regulatory complex with the 20S core.
CC Protects SUPT6H from proteasomal degradation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PSMC1, PSMC2, PSMC3, PSMC4, PSMC5 and PSMC6.
CC Interacts with SUPT6H. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat PAAF1/RPN14 family. {ECO:0000305}.
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DR EMBL; BC118307; AAI18308.1; -; mRNA.
DR RefSeq; NP_001069458.1; NM_001075990.1.
DR AlphaFoldDB; Q148I1; -.
DR SMR; Q148I1; -.
DR STRING; 9913.ENSBTAP00000004794; -.
DR PaxDb; Q148I1; -.
DR Ensembl; ENSBTAT00000004794; ENSBTAP00000004794; ENSBTAG00000003679.
DR GeneID; 533348; -.
DR KEGG; bta:533348; -.
DR CTD; 80227; -.
DR VEuPathDB; HostDB:ENSBTAG00000003679; -.
DR VGNC; VGNC:54890; PAAF1.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00390000005948; -.
DR HOGENOM; CLU_037051_1_0_1; -.
DR InParanoid; Q148I1; -.
DR OMA; QSDWSRA; -.
DR OrthoDB; 736374at2759; -.
DR TreeFam; TF313690; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000003679; Expressed in spermatocyte and 107 other tissues.
DR ExpressionAtlas; Q148I1; baseline and differential.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Proteasome; Reference proteome; Repeat; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9BRP4"
FT CHAIN 2..392
FT /note="Proteasomal ATPase-associated factor 1"
FT /id="PRO_0000284975"
FT REPEAT 90..129
FT /note="WD 1"
FT REPEAT 132..171
FT /note="WD 2"
FT REPEAT 174..215
FT /note="WD 3"
FT REPEAT 278..316
FT /note="WD 4"
FT REPEAT 360..392
FT /note="WD 5"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRP4"
SQ SEQUENCE 392 AA; 42194 MW; 17174B16E81BB305 CRC64;
MAAPLRIQSD WAQALRKDEG EAWLSCHPPG KPTLYGSLTC QGIGLDGIPE VTASEGFIVN
EINKKSIHVS CPKENVSSKF LAPYTTFSRI HTKSITCLDI SSGGGLGVSS SADGSMKIWQ
ASNGELRRVL EGHVFDVNCC RFFPSGLVVL SGGMDAQLKI WSAEDASCVV TFKGHKGGIL
DTAIVDRGKN VVSGSRDGTA RLWDCGRSAC LGVIADCGSS INGVAVGAAD NSINLGSPEQ
MPSEREVGTE SKMLLLARED KKLQCLGLQS RQPLFLFIGS DAFNCCTFLS GFLLLAGTQD
GNIYQLDVRN PRTPVQVIHR SGAPVMSLLS FRDGFIASQG DGSCFIVQQD LDYVIELTGA
DCDPVYKVAT WEKQIYTCCR DGLVRRYQLS DL
