ID   PAAF1_DICDI             Reviewed;         425 AA.
AC   Q8MYE8; Q54ZH6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Probable proteasomal ATPase-associated factor 1;
GN   Name=paaf1; ORFNames=DDB_G0277471;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Inhibits proteasome 26S assembly and activity by impairing
CC       the association of the 19S regulatory complex with the 20S core.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with proteasome 26S subunit ATPases. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PAAF1/RPN14 family. {ECO:0000305}.
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DR   EMBL; AAFI02000020; EAL68698.1; -; Genomic_DNA.
DR   RefSeq; XP_642666.1; XM_637574.1.
DR   AlphaFoldDB; Q8MYE8; -.
DR   SMR; Q8MYE8; -.
DR   STRING; 44689.DDB0169267; -.
DR   PaxDb; Q8MYE8; -.
DR   EnsemblProtists; EAL68698; EAL68698; DDB_G0277471.
DR   GeneID; 8621083; -.
DR   KEGG; ddi:DDB_G0277471; -.
DR   dictyBase; DDB_G0277471; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_037051_3_0_1; -.
DR   InParanoid; Q8MYE8; -.
DR   OMA; QSDWSRA; -.
DR   PhylomeDB; Q8MYE8; -.
DR   PRO; PR:Q8MYE8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Proteasome; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..425
FT                   /note="Probable proteasomal ATPase-associated factor 1"
FT                   /id="PRO_0000328749"
FT   REPEAT          101..140
FT                   /note="WD 1"
FT   REPEAT          143..182
FT                   /note="WD 2"
FT   REPEAT          185..224
FT                   /note="WD 3"
FT   REPEAT          299..341
FT                   /note="WD 4"
FT   REPEAT          345..382
FT                   /note="WD 5"
SQ   SEQUENCE   425 AA;  47096 MW;  79404C7387C0743C CRC64;
     MTSNTTEIPY HFLPYVRIQY DWQLAYKQDS DNCWVAYQKD LKNTIHGSVH STKIDENNFK
     FESDYGFKLT PNKENKNNIR VENDKYSIEI YAPEKQLKVS GGKKRITSMG VSHLGELGVY
     GSTDGTLEVF ETGDGQIRRK LDGHVGDVDL AMFFPSGRVI LSGSSDSRLK IWDAIEGTCA
     STLVGHIGGI TSASLVDRGR NLVSCSRDGT SKLWDIPTSS IISNLTKLSR PINDSFIASS
     LLDSIPTTTT TNSNDNNKVD EREVGTDGKT LIIAAEEGFL QAIDLRSKNM ISQMNVVQSG
     EKSTRSVAFN ACHVHKNYII GGDHNGSIYF WDKRNLNSPF CRLQFTNSPI HHIKANSSNS
     KIANSIWVTS GDGCCFLLDL DKNQIITSLS GIDTDVVTSF NIVGNQAYLT SRDSIIRCYN
     NLLNI