PAA_STRCG
ID PAA_STRCG Reviewed; 1653 AA.
AC Q9LBG3;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Probable cell-surface antigen I/II;
DE AltName: Full=PAa {ECO:0000303|PubMed:11267788};
DE Flags: Precursor;
GN Name=paaA;
OS Streptococcus criceti.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=E49;
RX PubMed=11267788; DOI=10.1111/j.1574-6968.2001.tb10573.x;
RA Tamura H., Kikuchi T., Shirato R., Kato H.;
RT "Cloning and DNA sequencing of the surface protein antigen I/II (PAa) of
RT Streptococcus cricetus.";
RL FEMS Microbiol. Lett. 196:251-256(2001).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}.
CC -!- SIMILARITY: Belongs to the antigen I/II family. {ECO:0000305}.
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DR EMBL; AB042239; BAA95000.1; -; Genomic_DNA.
DR RefSeq; WP_004225946.1; NZ_UHFB01000005.1.
DR AlphaFoldDB; Q9LBG3; -.
DR SMR; Q9LBG3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.530.10; -; 1.
DR InterPro; IPR026345; Adh_isopep-form_adh_dom.
DR InterPro; IPR041324; AgI/II_N.
DR InterPro; IPR032300; Antigen_C.
DR InterPro; IPR021197; Cross-wall-target_lipo_motif.
DR InterPro; IPR013574; Glucan-bd_C/Surface_Ag-I/II_V.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR036234; SA_I/II_PAC_V_sf.
DR InterPro; IPR009578; Surface_Ag_rpt.
DR Pfam; PF18652; Adhesin_P1_N; 1.
DR Pfam; PF17998; AgI_II_C2; 1.
DR Pfam; PF16364; Antigen_C; 1.
DR Pfam; PF08363; GbpC; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF06696; Strep_SA_rep; 6.
DR SUPFAM; SSF74914; SSF74914; 1.
DR TIGRFAMs; TIGR04228; isopep_sspB_C2; 1.
DR TIGRFAMs; TIGR03726; strep_RK_lipo; 1.
DR PROSITE; PS51965; AG_I_II_AR; 6.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 3: Inferred from homology;
KW Cell wall; Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..1623
FT /note="Probable cell-surface antigen I/II"
FT /id="PRO_0000379119"
FT PROPEP 1624..1653
FT /note="Removed by sortase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000379120"
FT REPEAT 150..224
FT /note="Ag I/II A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01310"
FT REPEAT 225..306
FT /note="Ag I/II A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01310"
FT REPEAT 307..388
FT /note="Ag I/II A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01310"
FT REPEAT 389..470
FT /note="Ag I/II A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01310"
FT REPEAT 471..552
FT /note="Ag I/II A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01310"
FT REPEAT 553..634
FT /note="Ag I/II A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01310"
FT REPEAT 960..998
FT /note="P1"
FT /evidence="ECO:0000269|PubMed:11267788"
FT REPEAT 999..1037
FT /note="P2"
FT /evidence="ECO:0000269|PubMed:11267788"
FT REPEAT 1038..1066
FT /note="P3"
FT /evidence="ECO:0000269|PubMed:11267788"
FT REGION 56..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..616
FT /note="Heptad repeats of Y-[EQ]-X-X-L-A-X"
FT /evidence="ECO:0000269|PubMed:11267788"
FT REGION 629..951
FT /note="V-region (lectin-like)"
FT /evidence="ECO:0000250"
FT REGION 975..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1620..1624
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT COMPBIAS 117..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..994
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1033
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1072
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1623
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ SEQUENCE 1653 AA; 180863 MW; 93F28E215BF598DE CRC64;
MKRKETFGFR KSKISKSLCG ALLGTAIVVS VAGQRALAED MTTSTTSAVD TTAVVGTETG
NPATNLPEKQ ADSSSQAEAS QAQAEQKTGS MPVDVATTEL DEAVKSAAEA GVTVSQDETV
DKGTVGTSQE ADEKSGEIKA DYSKQAETIK ITTETYKADV AANQSETNRI NQENAAKKAQ
YEQDLAANKA EVERITNKNA QAKADYEAKL AQYQKELAAV QQANSDNQAA YAAAKDAYEK
ELARVQKANA DAKAAYEQAV AANTAKNEQI KAANAAIQQR NAQAKADYEA KLAQYQKDLA
AVQAGNAANE ADYQAKKTAY EQELARVQAA NAAAKTAYEQ AVAANTAKNE QIKAANTAIQ
QRNAQAKADY EAKLAQYQND LAVVQAGNAA NEADYQAKKT AYEQELARVQ AANAAAKTAY
EQAVAANTAK NEEIKAANEA IKQRNAQAKA DYEAKLAQYQ KDLAAVQTGN AANEADYQAK
KTAYDQELAR VQKANADAKA AYDQAVKDNQ AKNAEIAAEN AAIRQRNAAA KADYEAKLAQ
YQKDLAAVQK ANAANEADYQ AKKLAYETEL ARVQKANADA KAAYDQAVKD NQAKNAEIAA
ENAAIRQRNA AAKADYEAKL AKYQQDLTQY QKDFADYQSK LKAYEDAQAA YKAALAELEK
HKNDDGYLPS PESQPFIFEQ EKNATLEITS GDKVYNADEF YAEADKLDYI KADTLFNTEK
RRVAYEHFKG GIQDSADWPG KRVFLPKGKP VVARYSNLKN SELNGKKIAS AEFIYTLKDT
SLNADKIPAM LYDDPTQTIY YFEFFGSQSI DVDIKFYDED GNKIDATGAL LDFSSLNRGH
GWPQYNGINT IEKVNYHTGT AIEINGSSVK DNGDGLYAAT PNYTKANQSR FESNEWDTTN
SPVNWYGAIV GKQTGPDIKF TLSAENASGI WFAFDSKIKA KDIPNKPMES EPTPPVAPTQ
PLEPVYEVEK DLEPVPVEPN YDPEPTPPTR TPDQPEPNKP DEPNYEVEKP SEPAPIEPNY
DPEPTPPTRT PDQPEPNKPD EPNYEVEQPQ EPAPVEPKYD PEPTPPVDPV YEKIPDPVNV
PTVRYHYYKL AIQPGVTKAI KNSDNLDIDK TLVAKQSTVK FQLLTADLPA GRPETTSFVL
VDPLPSGYQF NLEATKVASP GFDTSYDEAT NTVTFTATAE TLANLNKDLT KTVSTIYPTI
VGQVLNDGAI YTNNFTLTVN DAYGIKSNIV RVTTPGKPND PKHPNNSYIK PHKVNKNENG
VVIDGKAVLA GSTNYYELTW DLDQYKGDSS GKESIQKGFF YLEDYPEEAL DLRPDLVKIT
DTSGKAVTGI SVTDYASLEA APEMVREMLQ KANITPKGAF QLFTADNPQA FYDTYVVKGI
DLTIVTPMVV KAEMGKTGGG YENRAYQIDF GNGYESNPVI NNVPKIDPKK DVTLTLDPAD
LTNIDGQTIA LNQTFNYRLI GGIIPPKHAE ELFEYSFDDD YDQTGDKYTG QYKAFAKVDF
TLKDGTIIKA GTDLTQYTKA QIDEVNGRIL VSFKEDFLRS VSVDSAFQAE VYLQMKRIAV
GTFENTYVNT VNGITYSSNT VRTSTPEPKT PEDPRTSHTV VYRPIKDKTY QPAPPQTGQL
PATGDANNAY MPLLGLVSLT AGFSLLGLRR KKN
