PAB4L_HUMAN
ID PAB4L_HUMAN Reviewed; 370 AA.
AC P0CB38;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Polyadenylate-binding protein 4-like;
DE Short=PABP-4-like;
DE Short=Poly(A)-binding protein 4-like;
GN Name=PABPC4L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 220-370.
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May bind RNA. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000305}.
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DR EMBL; AC015631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX648831; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0CB38; -.
DR SMR; P0CB38; -.
DR IntAct; P0CB38; 22.
DR STRING; 9606.ENSP00000463233; -.
DR iPTMnet; P0CB38; -.
DR PhosphoSitePlus; P0CB38; -.
DR BioMuta; PABPC4L; -.
DR DMDM; 259515737; -.
DR EPD; P0CB38; -.
DR jPOST; P0CB38; -.
DR MassIVE; P0CB38; -.
DR MaxQB; P0CB38; -.
DR PaxDb; P0CB38; -.
DR PeptideAtlas; P0CB38; -.
DR PRIDE; P0CB38; -.
DR ProteomicsDB; 52433; -.
DR Antibodypedia; 68021; 54 antibodies from 9 providers.
DR Ensembl; ENST00000421491.4; ENSP00000463233.1; ENSG00000254535.4.
DR MANE-Select; ENST00000421491.4; ENSP00000463233.1; NM_001114734.2; NP_001108206.3.
DR UCSC; uc010ioe.4; human.
DR GeneCards; PABPC4L; -.
DR HGNC; HGNC:31955; PABPC4L.
DR HPA; ENSG00000254535; Tissue enhanced (placenta).
DR neXtProt; NX_P0CB38; -.
DR OpenTargets; ENSG00000254535; -.
DR VEuPathDB; HostDB:ENSG00000254535; -.
DR eggNOG; KOG0123; Eukaryota.
DR GeneTree; ENSGT00940000163344; -.
DR HOGENOM; CLU_012062_22_6_1; -.
DR InParanoid; P0CB38; -.
DR OMA; SRVKVMQ; -.
DR PhylomeDB; P0CB38; -.
DR PathwayCommons; P0CB38; -.
DR SignaLink; P0CB38; -.
DR ChiTaRS; PABPC4L; human.
DR Pharos; P0CB38; Tdark.
DR PRO; PR:P0CB38; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P0CB38; protein.
DR Bgee; ENSG00000254535; Expressed in caput epididymis and 103 other tissues.
DR Genevisible; P0CB38; HS.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 4.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR TIGRFAMs; TIGR01628; PABP-1234; 1.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..370
FT /note="Polyadenylate-binding protein 4-like"
FT /id="PRO_0000383673"
FT DOMAIN 10..88
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 98..174
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 190..267
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 293..369
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VARIANT 192
FT /note="V -> I (in dbSNP:rs10009368)"
FT /id="VAR_060185"
FT VARIANT 331
FT /note="S -> N (in dbSNP:rs6830036)"
FT /id="VAR_060186"
FT VARIANT 370
FT /note="H -> P (in dbSNP:rs11099273)"
FT /id="VAR_060187"
SQ SEQUENCE 370 AA; 41854 MW; AB7E61B91610E49A CRC64;
MNVAAKYRMA SLYVGDLHAD VTEDLLFRKF STVGPVLSIR ICRDQVTRRS LGYAYVNFLQ
LADAQKALDT MNFDIIKGKS IRLMWSQRDA YLRRSGIGNV FIKNLDKSID NKTLYEHFSA
FGKILSSKVM SDDQGSKGYA FVHFQNQSAA DRAIEEMNGK LLKGCKVFVG RFKNRKDREA
ELRSKASEFT NVYIKNFGGD MDDERLKDVF SKYGKTLSVK VMTDSSGKSK GFGFVSFDSH
EAAKKAVEEM NGRDINGQLI FVGRAQKKVE RQAELKQMFE QLKRERIRGC QGVKLYIKNL
DDTIDDEKLR NEFSSFGSIS RVKVMQEEGQ SKGFGLICFS SPEDATKAMT EMNGRILGSK
PLSIALAQRH
