PABP5_PONPY
ID PABP5_PONPY Reviewed; 382 AA.
AC P60050; Q95J70;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Polyadenylate-binding protein 5;
DE Short=PABP-5;
DE Short=Poly(A)-binding protein 5;
GN Name=PABPC5; Synonyms=PABP5;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11374897; DOI=10.1006/geno.2001.6530;
RA Blanco P., Sargent C.A., Boucher C.A., Howell G., Ross M., Affara N.A.;
RT "A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific
RT subinterval in the Xq21.3/Yp11.2 homology block of the human sex
RT chromosomes.";
RL Genomics 74:1-11(2001).
CC -!- FUNCTION: Binds the poly(A) tail of mRNA. May be involved in
CC cytoplasmic regulatory processes of mRNA metabolism. Can probably bind
CC to cytoplasmic RNA sequences other than poly(A) in vivo (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AJ299079; CAC42822.1; -; Genomic_DNA.
DR AlphaFoldDB; P60050; -.
DR SMR; P60050; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 4.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR TIGRFAMs; TIGR01628; PABP-1234; 1.
DR PROSITE; PS50102; RRM; 4.
PE 3: Inferred from homology;
KW Cytoplasm; Repeat; RNA-binding.
FT CHAIN 1..382
FT /note="Polyadenylate-binding protein 5"
FT /id="PRO_0000081709"
FT DOMAIN 18..96
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 106..182
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 199..276
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 302..378
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 382 AA; 43331 MW; 23B34751780C602B CRC64;
MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC RDPVTRSPLG
YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL RKSGVGNIFI KNLDKSIDNR
ALFYLFSAFG NILSCKVVCD DNGSKGYAYV HFDSLAAANR AIWHMNGVRL NNRQVYVGRF
KFPEERAAEV RTRDRATFTN VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG
FGFVRYETHE AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP
GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS FEEATKAVDE
MNGRIVGSKP LHVTLGQARR RC