PABP6_ARATH
ID PABP6_ARATH Reviewed; 537 AA.
AC O04319;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Polyadenylate-binding protein 6;
DE Short=PABP-6;
DE Short=Poly(A)-binding protein 6;
GN Name=PAB6; OrderedLocusNames=At3g16380; ORFNames=MYA6.18, T2O4.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND TISSUE SPECIFICITY.
RX PubMed=12586718; DOI=10.1093/genetics/163.1.311;
RA Belostotsky D.A.;
RT "Unexpected complexity of poly(A)-binding protein gene families in
RT flowering plants: three conserved lineages that are at least 200 million
RT years old and possible auto- and cross-regulation.";
RL Genetics 163:311-319(2003).
CC -!- FUNCTION: Binds the poly(A) tail of mRNA. Appears to be an important
CC mediator of the multiple roles of the poly(A) tail in mRNA biogenesis,
CC stability and translation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in leaves and young
CC seedlings. {ECO:0000269|PubMed:12586718}.
CC -!- MISCELLANEOUS: A.thaliana contains 8 PABP genes.
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000305}.
CC -!- CAUTION: Lacks the PABC domain, which is one of the conserved features
CC of the PAPB family. {ECO:0000305}.
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DR EMBL; AB023046; BAB01277.1; -; Genomic_DNA.
DR EMBL; AC001645; AAB63640.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75805.1; -; Genomic_DNA.
DR RefSeq; NP_188259.1; NM_112509.2.
DR AlphaFoldDB; O04319; -.
DR SMR; O04319; -.
DR STRING; 3702.AT3G16380.1; -.
DR iPTMnet; O04319; -.
DR PaxDb; O04319; -.
DR PRIDE; O04319; -.
DR ProteomicsDB; 226048; -.
DR EnsemblPlants; AT3G16380.1; AT3G16380.1; AT3G16380.
DR GeneID; 820885; -.
DR Gramene; AT3G16380.1; AT3G16380.1; AT3G16380.
DR KEGG; ath:AT3G16380; -.
DR Araport; AT3G16380; -.
DR TAIR; locus:2094922; AT3G16380.
DR eggNOG; KOG0123; Eukaryota.
DR HOGENOM; CLU_012062_22_6_1; -.
DR InParanoid; O04319; -.
DR OMA; KCIDNRA; -.
DR OrthoDB; 1027234at2759; -.
DR PhylomeDB; O04319; -.
DR PRO; PR:O04319; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; O04319; baseline and differential.
DR Genevisible; O04319; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0016071; P:mRNA metabolic process; TAS:TAIR.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006413; P:translational initiation; TAS:TAIR.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; SSF54928; 3.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; RNA-binding;
KW Translation regulation.
FT CHAIN 1..537
FT /note="Polyadenylate-binding protein 6"
FT /id="PRO_0000422644"
FT DOMAIN 21..99
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 112..188
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 202..279
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 304..381
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 503..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 60353 MW; 1FCCF26F157AA6EA CRC64;
MALVKTETQA LGNHQHSSRF GSLYVGDLSP DVTEKDLIDK FSLNVPVVSV HLCRNSVTGK
SMCYAYINFD SPFSASNAMT RLNHSDLKGK AMRIMWSQRD LAYRRRTRTG FANLYVKNLD
SSITSSCLER MFCPFGSILS CKVVEENGQS KGFGFVQFDT EQSAVSARSA LHGSMVYGKK
LFVAKFINKD ERAAMAGNQD STNVYVKNLI ETVTDDCLHT LFSQYGTVSS VVVMRDGMGR
SRGFGFVNFC NPENAKKAME SLCGLQLGSK KLFVGKALKK DERREMLKQK FSDNFIAKPN
MRWSNLYVKN LSESMNETRL REIFGCYGQI VSAKVMCHEN GRSKGFGFVC FSNCEESKQA
KRYLNGFLVD GKPIVVRVAE RKEDRIKRLQ QYFQAQPRQY TQAPSAPSPA QPVLSYVSSS
YGCFQPFQVG TSYYYMGNQV PQMSGHQNIT TYVPAGKVPL KERRSMHLVY KHPAYPVAKR
GAKQTLVFKG EVNRNLEAAT CSKATTSEEN RKEERRLTLS GKLSPEVKVE ESGKQLQ
