PABP7_ARATH
ID PABP7_ARATH Reviewed; 609 AA.
AC Q9ZQA8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Polyadenylate-binding protein 7;
DE Short=PABP-7;
DE Short=Poly(A)-binding protein 7;
GN Name=PAB7; OrderedLocusNames=At2g36660; ORFNames=F13K3.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-609.
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND TISSUE SPECIFICITY.
RX PubMed=12586718; DOI=10.1093/genetics/163.1.311;
RA Belostotsky D.A.;
RT "Unexpected complexity of poly(A)-binding protein gene families in
RT flowering plants: three conserved lineages that are at least 200 million
RT years old and possible auto- and cross-regulation.";
RL Genetics 163:311-319(2003).
CC -!- FUNCTION: Binds the poly(A) tail of mRNA. Appears to be an important
CC mediator of the multiple roles of the poly(A) tail in mRNA biogenesis,
CC stability and translation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in siliques.
CC {ECO:0000269|PubMed:12586718}.
CC -!- MISCELLANEOUS: A.thaliana contains 8 PABP genes.
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX819570; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC006282; AAD20142.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09279.1; -; Genomic_DNA.
DR EMBL; BX819570; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; B84783; B84783.
DR RefSeq; NP_181204.1; NM_129221.2.
DR AlphaFoldDB; Q9ZQA8; -.
DR SMR; Q9ZQA8; -.
DR STRING; 3702.AT2G36660.1; -.
DR PaxDb; Q9ZQA8; -.
DR PRIDE; Q9ZQA8; -.
DR ProteomicsDB; 248743; -.
DR EnsemblPlants; AT2G36660.1; AT2G36660.1; AT2G36660.
DR GeneID; 818238; -.
DR Gramene; AT2G36660.1; AT2G36660.1; AT2G36660.
DR KEGG; ath:AT2G36660; -.
DR Araport; AT2G36660; -.
DR TAIR; locus:2040625; AT2G36660.
DR eggNOG; KOG0123; Eukaryota.
DR HOGENOM; CLU_012062_22_4_1; -.
DR InParanoid; Q9ZQA8; -.
DR OMA; CKFGDIL; -.
DR OrthoDB; 1027234at2759; -.
DR PhylomeDB; Q9ZQA8; -.
DR PRO; PR:Q9ZQA8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZQA8; baseline and differential.
DR Genevisible; Q9ZQA8; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00658; PABP; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00360; RRM; 4.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; SSF54928; 3.
DR SUPFAM; SSF63570; SSF63570; 1.
DR TIGRFAMs; TIGR01628; PABP-1234; 1.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; RNA-binding;
KW Translation regulation.
FT CHAIN 1..609
FT /note="Polyadenylate-binding protein 7"
FT /id="PRO_0000081717"
FT DOMAIN 24..102
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 112..189
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 201..278
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 304..381
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 509..586
FT /note="PABC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00641"
FT CONFLICT 484
FT /note="Q -> E (in Ref. 3; BX819570)"
FT /evidence="ECO:0000305"
FT CONFLICT 497
FT /note="K -> T (in Ref. 3; BX819570)"
FT /evidence="ECO:0000305"
FT CONFLICT 527
FT /note="Q -> K (in Ref. 3; BX819570)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 609 AA; 67918 MW; DD20107123CA6848 CRC64;
MATVHAALHA ADASSSGSSS PVTASLYVGD LHPSVTEGIL YDAFAEFKSL TSVRLCKDAS
SGRSLCYGYA NFLSRQDANL AIEKKNNSLL NGKMIRVMWS VRAPDARRNG VGNVFVKNLP
ESVTNAVLQD MFKKFGNIVS CKVATLEDGK SRGYGFVQFE QEDAAHAAIQ TLNSTIVADK
EIYVGKFMKK TDRVKPEEKY TNLYMKNLDA DVSEDLLREK FAEFGKIVSL AIAKDENRLC
RGYAFVNFDN PEDARRAAET VNGTKFGSKC LYVGRAQKKA EREQLLREQF KEKHEEQKMI
AKVSNIYVKN VNVAVTEEEL RKHFSQCGTI TSTKLMCDEK GKSKGFGFVC FSTPEEAIDA
VKTFHGQMFH GKPLYVAIAQ KKEDRKMQLQ VQFGNRVEAR KSSSSASVNP GTYAPLYYTN
THPGMVYQSY PLMWKSANMI GSSYPNSEAV TYPPMVANAP SKNRQNRIGK LDRNAVSYVP
NVYQSTQMLP LSRDFSKQQH SRTYGRGKEM KKSIQQRQSE TVGMEMQLLG ELLHPLVEKL
EPQLANKITG MLLEMDKSEL LLLLKSPEDL AVRVDEAFEV LKSSKTNLTA PNTHRSDYLA
SGIAGVSIK
