PABPX_SCHPO
ID PABPX_SCHPO Reviewed; 710 AA.
AC Q9P6M8; Q8X1D3; Q96WR4;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=mRNA export factor crp79;
DE AltName: Full=Meiotic expression up-regulated protein 5;
DE AltName: Full=Polyadenylate-binding protein crp79;
DE Short=PABP;
DE Short=Poly(A)-binding protein;
GN Name=crp79; Synonyms=meu5; ORFNames=SPAC1610.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12181330; DOI=10.1091/mbc.e01-11-0133;
RA Thakurta A.G., Whalen W.A., Yoon J.H., Bharathi A., Kozak L., Whiteford C.,
RA Love D.C., Hanover J.A., Dhar R.;
RT "Crp79p, like Mex67p, is an auxiliary mRNA export factor in
RT Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 13:2571-2584(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 270-487.
RC STRAIN=CD16-1;
RX PubMed=11376151; DOI=10.1093/nar/29.11.2327;
RA Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y.,
RA Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.;
RT "Comprehensive isolation of meiosis-specific genes identifies novel
RT proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.";
RL Nucleic Acids Res. 29:2327-2337(2001).
CC -!- FUNCTION: Binds the poly(A) tail of mRNA. Involved in the export of
CC mRNA from the nucleus to the cytoplasm. {ECO:0000269|PubMed:12181330}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181330}. Nucleus
CC {ECO:0000269|PubMed:12181330}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF432874; AAL65912.1; -; Genomic_DNA.
DR EMBL; CU329670; CAD99126.1; -; Genomic_DNA.
DR EMBL; AB054316; BAB60882.1; -; mRNA.
DR RefSeq; NP_001018242.1; NM_001018920.2.
DR AlphaFoldDB; Q9P6M8; -.
DR BioGRID; 280597; 88.
DR STRING; 4896.SPAC1610.03c.1; -.
DR PaxDb; Q9P6M8; -.
DR EnsemblFungi; SPAC1610.03c.1; SPAC1610.03c.1:pep; SPAC1610.03c.
DR GeneID; 3361521; -.
DR KEGG; spo:SPAC1610.03c; -.
DR PomBase; SPAC1610.03c; crp79.
DR VEuPathDB; FungiDB:SPAC1610.03c; -.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_400179_0_0_1; -.
DR InParanoid; Q9P6M8; -.
DR OMA; LACYPNS; -.
DR PhylomeDB; Q9P6M8; -.
DR Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SPO-72649; Translation initiation complex formation.
DR Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q9P6M8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IDA:PomBase.
DR GO; GO:0003723; F:RNA binding; IDA:PomBase.
DR GO; GO:0006406; P:mRNA export from nucleus; IGI:PomBase.
DR GO; GO:0048255; P:mRNA stabilization; IMP:PomBase.
DR GO; GO:1902373; P:negative regulation of mRNA catabolic process; IMP:PomBase.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR CDD; cd12355; RRM_RBM18; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039157; RBM18_RRM.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 3.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Cytoplasm; mRNA transport; Nucleus; Reference proteome; Repeat;
KW RNA-binding; Transport.
FT CHAIN 1..710
FT /note="mRNA export factor crp79"
FT /id="PRO_0000081719"
FT DOMAIN 19..102
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 222..292
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 401..474
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 333..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 101
FT /note="T -> A (in Ref. 1; AAL65912)"
FT /evidence="ECO:0000305"
FT CONFLICT 580
FT /note="N -> K (in Ref. 1; AAL65912)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 710 AA; 79062 MW; 8DB7ACCB46C8A9E8 CRC64;
MNNSKLSVPG QYEDESSTIY VGNIDSRLSD EEIIKHFSKY GQVESIFRRL LDSFYPKEKA
KPFKPPKNGV QYGFVKFVNA ESIEEVLKDA KGMTLGQRKL TIKARVVNPA KLTDKKFKPN
DTSITANVFN PSIQNNTDEE NVKPGLKQSQ IKEFIPNVEE RNWETVRGIN SRNPKPETTL
TIPSLGLEDI SMQVVPNAFA STLPLSILNL PAEVTPIDLY NHFKQAGVVK GTAVSQFLDQ
RGFRYGEVIM DSVESCQNAI EKLNNVPYKG SILEVSIKNK ASSSVKSIPT TPTGESLWPF
PSENANKTQI NIENATCSKM TWIMGSPTKE KSQWGSVSTT GVSNQQNHPA AWNPDNKPQS
IVHWDSLRES SPSIPNSPID PSNLYVKNLD DTVITCKSQL EDLFSPFGSI LSSMLACYPN
SGISKGYGFV AFRQIEAAVR AKDTLNGMMV GKKRIFVCFA ERKSDRIRRL QAFFANKPTS
EQTAQQDNKA LFVKPERSST VTIRKPIESS TNKISENPTT LSSKVENKNE PKTGENKEPS
QTNEYVNCKQ ENKELSGQLS GNLDIKKEAG KLSHDGEQGN LLKPLVFHAN TKLNNRGSAK
MGSTATNLKK IQDMLHNKKL SNAYFVPRAR ATTCTTLTYV TVEPSHFQDE DCNESTNMLS
LVGYMDSYPE ATSNIQKMNS YHIKDSNKEN FLSTTKVNNN SPTTIQLTQI
