ID   PABP_ENCCU              Reviewed;         502 AA.
AC   Q8SR30;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Polyadenylate-binding protein, cytoplasmic and nuclear;
DE            Short=PABP;
DE            Short=Poly(A)-binding protein;
DE   AltName: Full=Polyadenylate tail-binding protein;
GN   Name=PAB1; OrderedLocusNames=ECU10_1110;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Binds the poly(A) tail of mRNA. Appears to be an important
CC       mediator of the multiple roles of the poly(A) tail in mRNA biogenesis,
CC       stability and translation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590449; CAD25830.1; -; Genomic_DNA.
DR   RefSeq; NP_586226.1; NM_001042059.1.
DR   AlphaFoldDB; Q8SR30; -.
DR   SMR; Q8SR30; -.
DR   STRING; 284813.Q8SR30; -.
DR   GeneID; 859875; -.
DR   KEGG; ecu:ECU10_1110; -.
DR   VEuPathDB; MicrosporidiaDB:ECU10_1110; -.
DR   HOGENOM; CLU_012062_22_6_1; -.
DR   InParanoid; Q8SR30; -.
DR   OMA; KCIDNRA; -.
DR   OrthoDB; 1027234at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 4.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 4.
DR   SMART; SM00360; RRM; 4.
DR   SUPFAM; SSF54928; SSF54928; 3.
DR   PROSITE; PS50102; RRM; 4.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..502
FT                   /note="Polyadenylate-binding protein, cytoplasmic and
FT                   nuclear"
FT                   /id="PRO_0000295391"
FT   DOMAIN          14..90
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          96..176
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          191..275
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          299..376
FT                   /note="RRM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   502 AA;  56508 MW;  B7F58378B95A2C32 CRC64;
     MEIDESKRAS SDSLTIYVGE LSPKTLDSDL FRVFSNVGKV LSVKLIKRAE PVSSFAFVTF
     ENEEDAERAI REYKHYELHN RQIRVMKKDE RPPETGNIFV KNLPEDFTGK DLDDAFSMFG
     EIVSCKVATT SHGKSKGYGF VQFKEKKAAK KVIKNFSSLD GLLLGGNRIV VELYNPEIKK
     GESKKTSATF TNCFIKNFPF DASEAELLEL LERYGKVTSL FFPVKDNGKP KGFAFANFEN
     HESALNAIKN LHGTFPFGAG RDGTGEAFYI QKGQRKEERA EELRKMFEQM SMQGQSYKKN
     LYITNIPEGF GCEELGSIFK EFGNITSISV GVDGANSQKQ YAYICYSTPE EASIAVERGN
     EIYLDGNRLQ VAYFKNKLER MKEKEFGGGL GYKPGVPYMY NQGVSFASRG FKRERNRGGA
     AKPYGNELEK LHSLVLAAAP SFKSQWKDFG VGNEVEFANK VIRAFRSRSE EEIKDMIDLN
     FVLTKNIASA IEDDNSNDQV LL