ASK17_ARATH
ID ASK17_ARATH Reviewed; 150 AA.
AC Q9SL65;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=SKP1-like protein 17;
DE Short=AtSK17;
DE AltName: Full=Protein MEIDOS;
GN Name=ASK17; Synonyms=MEO; OrderedLocusNames=At2g20160; ORFNames=T2G17.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INDUCTION.
RX PubMed=12815071; DOI=10.1101/gad.257403;
RA Koehler C., Hennig L., Spillane C., Pien S., Gruissem W., Grossniklaus U.;
RT "The Polycomb-group protein MEDEA regulates seed development by controlling
RT expression of the MADS-box gene PHERES1.";
RL Genes Dev. 17:1540-1553(2003).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=12970487; DOI=10.1104/pp.103.024703;
RA Zhao D., Ni W., Feng B., Han T., Petrasek M.G., Ma H.;
RT "Members of the Arabidopsis-SKP1-like gene family exhibit a variety of
RT expression patterns and may play diverse roles in Arabidopsis.";
RL Plant Physiol. 133:203-217(2003).
RN [5]
RP FUNCTION.
RX PubMed=16824920; DOI=10.1016/j.cub.2006.05.045;
RA Josefsson C., Dilkes B., Comai L.;
RT "Parent-dependent loss of gene silencing during interspecies
RT hybridization.";
RL Curr. Biol. 16:1322-1328(2006).
RN [6]
RP INTERACTION WITH CPR1/CPR30.
RX PubMed=19682297; DOI=10.1111/j.1365-313x.2009.03995.x;
RA Gou M., Su N., Zheng J., Huai J., Wu G., Zhao J., He J., Tang D., Yang S.,
RA Wang G.;
RT "An F-box gene, CPR30, functions as a negative regulator of the defense
RT response in Arabidopsis.";
RL Plant J. 60:757-770(2009).
CC -!- FUNCTION: Involved in ubiquitination and subsequent proteasomal
CC degradation of target proteins. Together with CUL1, RBX1 and a F-box
CC protein, it forms a SCF E3 ubiquitin ligase complex. The functional
CC specificity of this complex depends on the type of F-box protein. In
CC the SCF complex, it serves as an adapter that links the F-box protein
CC to CUL1 (By similarity). Probably implicated in incompatibility
CC response after hybridization. {ECO:0000250,
CC ECO:0000269|PubMed:16824920}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with CPR1/CPR30. {ECO:0000250,
CC ECO:0000269|PubMed:19682297}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mainly detected in the siliques.
CC {ECO:0000269|PubMed:12970487}.
CC -!- INDUCTION: Repressed by MEA and the polycomb repressive complex (PRC).
CC {ECO:0000269|PubMed:12815071}.
CC -!- MISCELLANEOUS: This protein was called 'Meidos' in memory of one of the
CC murdered sons of the mythological 'Medea', as MEIDOS is repressed by
CC MEDEA.
CC -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR EMBL; AC006081; AAD24382.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06973.1; -; Genomic_DNA.
DR PIR; G84585; G84585.
DR RefSeq; NP_565467.1; NM_127575.2.
DR AlphaFoldDB; Q9SL65; -.
DR SMR; Q9SL65; -.
DR BioGRID; 1890; 15.
DR ComplexPortal; CPX-1444; SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17.
DR ComplexPortal; CPX-1465; SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17.
DR ComplexPortal; CPX-1487; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17.
DR ComplexPortal; CPX-1510; SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK17.
DR ComplexPortal; CPX-1530; SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17.
DR ComplexPortal; CPX-1551; SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17.
DR ComplexPortal; CPX-1573; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17.
DR ComplexPortal; CPX-1594; SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK17.
DR IntAct; Q9SL65; 3.
DR STRING; 3702.AT2G20160.1; -.
DR PaxDb; Q9SL65; -.
DR PRIDE; Q9SL65; -.
DR ProteomicsDB; 246508; -.
DR EnsemblPlants; AT2G20160.1; AT2G20160.1; AT2G20160.
DR GeneID; 816536; -.
DR Gramene; AT2G20160.1; AT2G20160.1; AT2G20160.
DR KEGG; ath:AT2G20160; -.
DR Araport; AT2G20160; -.
DR TAIR; locus:2061709; AT2G20160.
DR eggNOG; KOG1724; Eukaryota.
DR HOGENOM; CLU_059252_6_1_1; -.
DR InParanoid; Q9SL65; -.
DR OMA; LAIIIEY; -.
DR OrthoDB; 1412723at2759; -.
DR PhylomeDB; Q9SL65; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9SL65; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SL65; baseline and differential.
DR Genevisible; Q9SL65; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IC:ComplexPortal.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IC:ComplexPortal.
DR GO; GO:0009867; P:jasmonic acid mediated signaling pathway; IMP:ComplexPortal.
DR GO; GO:0016567; P:protein ubiquitination; ISS:TAIR.
DR GO; GO:0009733; P:response to auxin; IC:ComplexPortal.
DR GO; GO:0009753; P:response to jasmonic acid; IMP:ComplexPortal.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR016897; SKP1.
DR InterPro; IPR001232; SKP1-like.
DR InterPro; IPR036296; SKP1-like_dim_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR016072; Skp1_comp_dimer.
DR InterPro; IPR016073; Skp1_comp_POZ.
DR PANTHER; PTHR11165; PTHR11165; 1.
DR Pfam; PF01466; Skp1; 1.
DR Pfam; PF03931; Skp1_POZ; 1.
DR PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR SMART; SM00512; Skp1; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF81382; SSF81382; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..150
FT /note="SKP1-like protein 17"
FT /id="PRO_0000375258"
FT REGION 92..150
FT /note="Interaction with the F-box domain of F-box proteins"
FT /evidence="ECO:0000250"
SQ SEQUENCE 150 AA; 17286 MW; A8B9E489CF9546DB CRC64;
MSSKKIVLTS SDDECFEIDE AVARKMQMVA HMIDDDCADK AIRLQNVTGK ILAIIIEYCK
KHVDDVEAKN EFVTWDAEFV KNIDMDTLFK LLDAADYLIV IGLKNLIAQA IADYTADKTV
NEIRELFNIE NDYTPEEEEE LRKKNEWAFN
