ID   PABT_STRGR              Reviewed;         361 AA.
AC   P33586;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Probable cadicidin biosynthesis thioesterase;
DE            EC=3.1.2.-;
DE   AltName: Full=ORF-1;
DE   AltName: Full=Protein X;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IMRU 3570;
RX   PubMed=8472954; DOI=10.1016/0378-1119(93)90602-y;
RA   Criado L.M., Martin J.F., Gil J.A.;
RT   "The pab gene of Streptomyces griseus, encoding p-aminobenzoic acid
RT   synthase, is located between genes possibly involved in candicidin
RT   biosynthesis.";
RL   Gene 126:135-139(1993).
CC   -!- FUNCTION: Probable thioesterase involved in the biosynthesis of
CC       candicidin. Could release the macrolide ring from the polyketide
CC       synthase.
CC   -!- PATHWAY: Antibiotic biosynthesis; candicidin biosynthesis.
CC   -!- SIMILARITY: Belongs to the thioesterase family. {ECO:0000305}.
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DR   EMBL; M93058; AAA72110.1; -; Unassigned_DNA.
DR   PIR; JN0530; JN0530.
DR   AlphaFoldDB; P33586; -.
DR   SMR; P33586; -.
DR   ESTHER; strgr-pabt; Thioesterase.
DR   UniPathway; UPA00101; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR012223; TEII.
DR   InterPro; IPR001031; Thioesterase.
DR   PANTHER; PTHR11487; PTHR11487; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Hydrolase.
FT   CHAIN           1..361
FT                   /note="Probable cadicidin biosynthesis thioesterase"
FT                   /id="PRO_0000180365"
FT   DOMAIN          2..29
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT   REGION          36..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        201
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   361 AA;  39559 MW;  2114BF0438F8950C CRC64;
     MRVTVDSEQC VGAGQCVLNA PEVFDQDDDG VVVLLRADPT SGTTRRSARR ATCARRPRSS
     SRRTEPAGCA DRHRCPVRPG PRTRGPADPP PANTDRRQNH RRDSPVTTAD DTAARWLRRY
     HPAEADAVRL VCFPHAGGSA SFYHPVSARF APGAEVVSLQ YPGRQDRRKE PCVPDLGTLA
     DLITEQLLPL DERPTVFFGH SMGAALAFET AWRLEQKGAG PRTVIASGRR GPSTTRAERV
     HTRDDDGIVA EMKRLNGTAA GVLGDEEILR MALPALRGDY RAIETYTCPP DRRLACGLTV
     LTGEDDPLTT VEEAERWRDH TTGPFRLRVF TGGHFFLTQH LDAVNTEIAQ ALHPDRAAPA
     A