ID   PAB_FINMA               Reviewed;         387 AA.
AC   Q51911;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Peptostreptococcal albumin-binding protein;
DE   Flags: Precursor;
GN   Name=pab;
OS   Finegoldia magna (Peptostreptococcus magnus).
OC   Bacteria; Firmicutes; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Finegoldia.
OX   NCBI_TaxID=1260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ALB8;
RX   PubMed=8163519; DOI=10.1016/s0021-9258(17)32693-5;
RA   de Chateau M., Bjoerck L.;
RT   "Protein PAB, a mosaic albumin-binding bacterial protein representing the
RT   first contemporary example of module shuffling.";
RL   J. Biol. Chem. 269:12147-12151(1994).
RN   [2]
RP   STRUCTURE BY NMR OF 213-265, AND SEQUENCE REVISION TO 244.
RC   STRAIN=ALB8;
RX   PubMed=9086265; DOI=10.1006/jmbi.1996.0856;
RA   Johansson M.U., de Chateau M., Wikstroem M., Forsen S., Drakenberg T.,
RA   Bjoerck L.;
RT   "Solution structure of the albumin-binding GA module: a versatile bacterial
RT   protein domain.";
RL   J. Mol. Biol. 266:859-865(1997).
CC   -!- FUNCTION: Binds serum albumin.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
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DR   EMBL; X77864; CAA54857.1; -; Genomic_DNA.
DR   PIR; A53586; A53586.
DR   PDB; 1GAB; NMR; -; A=213-265.
DR   PDB; 1PRB; NMR; -; A=213-265.
DR   PDB; 1TF0; X-ray; 2.70 A; B=213-265.
DR   PDB; 2J5Y; X-ray; 1.40 A; A/B=213-265.
DR   PDB; 2VDB; X-ray; 2.52 A; B=213-265.
DR   PDBsum; 1GAB; -.
DR   PDBsum; 1PRB; -.
DR   PDBsum; 1TF0; -.
DR   PDBsum; 2J5Y; -.
DR   PDBsum; 2VDB; -.
DR   AlphaFoldDB; Q51911; -.
DR   SMR; Q51911; -.
DR   DrugBank; DB03600; Capric acid.
DR   DrugBank; DB00788; Naproxen.
DR   EvolutionaryTrace; Q51911; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   InterPro; IPR040912; DUF5633.
DR   InterPro; IPR035152; GA-like.
DR   InterPro; IPR009063; Ig/albumin-bd_sf.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   Pfam; PF18656; DUF5633; 1.
DR   Pfam; PF17573; GA-like; 2.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   SUPFAM; SSF46997; SSF46997; 2.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell wall; Peptidoglycan-anchor; Secreted; Signal.
FT   SIGNAL          1..26
FT   CHAIN           27..358
FT                   /note="Peptostreptococcal albumin-binding protein"
FT                   /id="PRO_0000005643"
FT   PROPEP          359..387
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005644"
FT   REGION          122..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..265
FT                   /note="GA module"
FT   REGION          266..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           355..359
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        272..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         358
FT                   /note="Pentaglycyl murein peptidoglycan amidated alanine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   HELIX           214..232
FT                   /evidence="ECO:0007829|PDB:2J5Y"
FT   HELIX           238..246
FT                   /evidence="ECO:0007829|PDB:2J5Y"
FT   STRAND          247..249
FT                   /evidence="ECO:0007829|PDB:1PRB"
FT   HELIX           250..264
FT                   /evidence="ECO:0007829|PDB:2J5Y"
SQ   SEQUENCE   387 AA;  43058 MW;  3D5135C4C3A3D8F2 CRC64;
     MKLNKKLLMA ALAGAIVVGG GVNTFAADEP GAIKVDKAPE APSQELKLTK EEAEKALKKE
     KPIAKERLRR LGITSEFILN QIDKATSREG LESLVQTIKQ SYLKDHPIKE EKTEETPKYN
     NLFDKHELGG LGKDKGPGRF DENGWENNEH GYETRENAEK AAVKALGDKE INKSYTISQG
     VDGRYYYVLS REEAETPKKP EEKKPEDKRP KMTIDQWLLK NAKEDAIAEL KKAGITSDFY
     FNAINKAKTV EEVNALKNEI LKAHAGKEVN PSTPEVTPSV PQNHYHENDY ANIGAGEGTK
     EDGKKENSKE GIKRKTAREE KPGKEEKPAK EDKKENKKKE NTDSPNKKKK EKAALPEAGR
     RKAEILTLAA ASLSSVAGAF ISLKKRK