ID   PAC2_SCHPO              Reviewed;         235 AA.
AC   Q10294;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=cAMP-independent regulatory protein pac2;
GN   Name=pac2; ORFNames=SPAC31G5.11;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8536311; DOI=10.1007/bf00311879;
RA   Kunitomo H., Sugimoto A., Wilkinson C.R.M., Yamamoto M.;
RT   "Schizosaccharomyces pombe pac2+ controls the onset of sexual development
RT   via a pathway independent of the cAMP cascade.";
RL   Curr. Genet. 28:32-38(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD16-1;
RA   Watanabe T., Saito T.T., Nabeshima K., Nojima H.;
RT   "Identification of abundant polyA plus non-coding RNAs that are expressed
RT   in Schizosaccharomyces pombe.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Controls the onset of sexual development, by inhibiting the
CC       expression of ste11, in a pathway that is independent of the cAMP
CC       cascade.
CC   -!- SIMILARITY: To yeast YEL007w and to the N-terminal of S.pombe gti1.
CC       {ECO:0000305}.
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DR   EMBL; D43748; BAA07805.1; -; mRNA.
DR   EMBL; AB084888; BAC54908.1; -; mRNA.
DR   EMBL; CU329670; CAB11695.1; -; Genomic_DNA.
DR   PIR; S55723; S55723.
DR   RefSeq; NP_594011.1; NM_001019437.1.
DR   AlphaFoldDB; Q10294; -.
DR   SMR; Q10294; -.
DR   BioGRID; 278579; 79.
DR   STRING; 4896.SPAC31G5.11.1; -.
DR   MaxQB; Q10294; -.
DR   PaxDb; Q10294; -.
DR   EnsemblFungi; SPAC31G5.11.1; SPAC31G5.11.1:pep; SPAC31G5.11.
DR   GeneID; 2542103; -.
DR   KEGG; spo:SPAC31G5.11; -.
DR   PomBase; SPAC31G5.11; pac2.
DR   VEuPathDB; FungiDB:SPAC31G5.11; -.
DR   eggNOG; KOG4476; Eukaryota.
DR   HOGENOM; CLU_028895_3_1_1; -.
DR   InParanoid; Q10294; -.
DR   OMA; SHYSAPY; -.
DR   PhylomeDB; Q10294; -.
DR   PRO; PR:Q10294; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0031138; P:negative regulation of conjugation with cellular fusion; IMP:PomBase.
DR   GO; GO:0007165; P:signal transduction; NAS:PomBase.
DR   InterPro; IPR018608; Gti1/Pac2.
DR   PANTHER; PTHR28027; PTHR28027; 1.
DR   Pfam; PF09729; Gti1_Pac2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Meiosis; Reference proteome.
FT   CHAIN           1..235
FT                   /note="cAMP-independent regulatory protein pac2"
FT                   /id="PRO_0000058166"
FT   REGION          85..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   235 AA;  26106 MW;  163F337E5DC971F6 CRC64;
     MQTYTGIIKT PLDAIILFEA CRIGLLPRVQ RRLSDHERSL IRAGSVFVWD EREAGMRRWT
     DGKSWSASRV SGSFLTYREM EGKRKPYHHG LSTDGSLKRS PSADTTGNSS LNAYSNEDSG
     AASLSDEESV DDENLRGLHY KPNGLIKQSF SITTSLNHKL HLISYSSPIP DPSLVTPSSD
     VNLSRITIPY GLYPDAGPPL VQAPKFLAPY DILVEKVACS EDARVLDKLR QALWL