PACA_CHICK
ID PACA_CHICK Reviewed; 175 AA.
AC P41534; Q53WW0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Glucagon family neuropeptides;
DE Contains:
DE RecName: Full=Growth hormone-releasing factor 1-46;
DE Short=GRF;
DE AltName: Full=Growth hormone-releasing hormone;
DE Short=GHRH;
DE Contains:
DE RecName: Full=Pituitary adenylate cyclase-activating polypeptide 27;
DE Short=PACAP-27;
DE Short=PACAP27;
DE Contains:
DE RecName: Full=Pituitary adenylate cyclase-activating polypeptide 38;
DE Short=PACAP-38;
DE Short=PACAP38;
DE Flags: Precursor;
GN Name=ADCYAP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=9022048; DOI=10.1089/dna.1997.16.95;
RA McRory J.E., Parker R.L., Sherwood N.M.;
RT "Expression and alternative processing of a chicken gene encoding both
RT growth hormone-releasing hormone and pituitary adenylate cyclase-activating
RT polypeptide.";
RL DNA Cell Biol. 16:95-102(1997).
RN [2]
RP PROTEIN SEQUENCE OF 131-168, AND AMIDATION AT LEU-157 AND LYS-168.
RA Yasuhara T., Mizuno K., Somogyvari-Vigh A., Komaki G., Arimura A.;
RT "Isolation and primary structure of chicken PACAP.";
RL Regul. Pept. 37:326-326(1992).
CC -!- FUNCTION: Primary role of GRF is to release GH from the pituitary.
CC -!- FUNCTION: PACAP plays pivotal roles as a neurotransmitter and/or a
CC neuromodulator.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=GRF 1-46;
CC IsoId=P41534-1; Sequence=Displayed;
CC Name=GRF 1-43;
CC IsoId=P41534-2; Sequence=VSP_001760;
CC Name=GRF 33-46;
CC IsoId=P41534-3; Sequence=VSP_001759;
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR EMBL; U71183; AAB51200.1; -; mRNA.
DR EMBL; U71184; AAB51201.1; -; mRNA.
DR EMBL; U71185; AAB51202.1; -; mRNA.
DR EMBL; U67275; AAC64494.1; -; Genomic_DNA.
DR PIR; A61070; A61070.
DR AlphaFoldDB; P41534; -.
DR SMR; P41534; -.
DR VEuPathDB; HostDB:geneid_408251; -.
DR InParanoid; P41534; -.
DR PhylomeDB; P41534; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0044297; C:cell body; IDA:AgBase.
DR GO; GO:0070852; C:cell body fiber; IDA:AgBase.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IDA:AgBase.
DR GO; GO:0043204; C:perikaryon; IDA:AgBase.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR GO; GO:0016521; F:pituitary adenylate cyclase activating polypeptide activity; IBA:GO_Central.
DR GO; GO:0031858; F:pituitary adenylate cyclase-activating polypeptide receptor binding; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0002118; P:aggressive behavior; IMP:AgBase.
DR GO; GO:0042756; P:drinking behavior; IMP:AgBase.
DR GO; GO:0030073; P:insulin secretion; ISS:UniProtKB.
DR GO; GO:0040011; P:locomotion; IMP:AgBase.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; ISS:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IDA:AgBase.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR GO; GO:0035176; P:social behavior; IMP:AgBase.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR039080; PACAP.
DR PANTHER; PTHR11213; PTHR11213; 1.
DR PANTHER; PTHR11213:SF1; PTHR11213:SF1; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Direct protein sequencing; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..80
FT /id="PRO_0000011511"
FT PEPTIDE 83..128
FT /note="Growth hormone-releasing factor 1-46"
FT /id="PRO_0000011512"
FT PEPTIDE 131..168
FT /note="Pituitary adenylate cyclase-activating polypeptide
FT 38"
FT /id="PRO_0000011513"
FT PEPTIDE 131..157
FT /note="Pituitary adenylate cyclase-activating polypeptide
FT 27"
FT /id="PRO_0000011514"
FT PROPEP 172..175
FT /id="PRO_0000011515"
FT MOD_RES 157
FT /note="Leucine amide"
FT /evidence="ECO:0000269|Ref.2"
FT MOD_RES 168
FT /note="Lysine amide"
FT /evidence="ECO:0000269|Ref.2"
FT VAR_SEQ 82..114
FT /note="RHADGIFSKAYRKLLGQLSARNYLHSLMAKRVG -> S (in isoform
FT GRF 33-46)"
FT /evidence="ECO:0000305"
FT /id="VSP_001759"
FT VAR_SEQ 115..117
FT /note="Missing (in isoform GRF 1-43)"
FT /evidence="ECO:0000305"
FT /id="VSP_001760"
SQ SEQUENCE 175 AA; 19561 MW; 0DB54995F0AA9DFB CRC64;
MSGNVYKTLL TLLVYGLIMH CNVYCSPDRW TPVPGAKLEE EVYDEDGNTL QDFALRAGAP
GGGGPRPRWG RCTALYYPPG KRHADGIFSK AYRKLLGQLS ARNYLHSLMA KRVGGASSGL
GDEAEPLSKR HIDGIFTDSY SRYRKQMAVK KYLAAVLGKR YKQRVKNKGR RVAYL
