PACA_ONCNE
ID PACA_ONCNE Reviewed; 173 AA.
AC P41585;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Glucagon family neuropeptides;
DE Contains:
DE RecName: Full=Growth hormone-releasing factor;
DE Short=GRF;
DE AltName: Full=Growth hormone-releasing hormone;
DE Short=GHRH;
DE Contains:
DE RecName: Full=Pituitary adenylate cyclase-activating polypeptide;
DE Short=PACAP;
DE Flags: Precursor;
OS Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8023;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RC TISSUE=Brain;
RX PubMed=8344311; DOI=10.1111/j.1432-1033.1993.tb18051.x;
RA Parker D.B., Coe I.R., Dixon G.H., Sherwood N.M.;
RT "Two salmon neuropeptides encoded by one brain cDNA are structurally
RT related to members of the glucagon superfamily.";
RL Eur. J. Biochem. 215:439-448(1993).
CC -!- FUNCTION: Primary role of GHRH is to release GH from the pituitary.
CC -!- FUNCTION: PACAP plays pivotal roles as a neurotransmitter and/or a
CC neuromodulator.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P41585-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P41585-2; Sequence=VSP_001762, VSP_001763;
CC -!- MISCELLANEOUS: [Isoform Short]: Lacks the GHRH-like sequence.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X73233; CAA51705.1; ALT_SEQ; mRNA.
DR PIR; S34767; S34767.
DR AlphaFoldDB; P41585; -.
DR SMR; P41585; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11213; PTHR11213; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Hormone; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..80
FT /id="PRO_0000011525"
FT PEPTIDE 82..126
FT /note="Growth hormone-releasing factor"
FT /id="PRO_0000011526"
FT PEPTIDE 129..166
FT /note="Pituitary adenylate cyclase-activating polypeptide"
FT /id="PRO_0000011527"
FT PROPEP 170..173
FT /id="PRO_0000011528"
FT MOD_RES 166
FT /note="Lysine amide"
FT /evidence="ECO:0000255"
FT VAR_SEQ 78
FT /note="G -> S (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001762"
FT VAR_SEQ 79..113
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001763"
FT VARIANT 22
FT /note="S -> C"
FT VARIANT 61
FT /note="P -> S"
FT VARIANT 78
FT /note="G -> R"
FT VARIANT 122
FT /note="T -> S"
FT VARIANT 165
FT /note="N -> S"
FT VARIANT 171
FT /note="G -> A"
SQ SEQUENCE 173 AA; 19704 MW; 2B0B554F43C738F2 CRC64;
MSSKATLALL IYGIIMHYSV YSSPLGLNYP NLRLENEVYD EDGNSLPALA FDSDQIAIRS
PPSVADDLYT LYYPPEKGTE RHADGMFNKA YRKALGQLSA RKYLHSLMAK RVGGGSTMED
DTEPLSKRHS DGIFTDSYSR YRKQMAVKKY LAAVLGKRYR QRYRNKGRRL GYL
